PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31684176-9 2019 Eugenol increased caspase-3 activity and the expression of Bax, cytochrome c (Cyt-c), caspase-3, and caspase-9 and decreased the expression of B-cell lymphoma (Bcl)-2, cyclooxygenase-2 (Cox-2), and interleukin-1 beta (IL-1beta) indicating that eugenol mainly induced cell death by apoptosis. Eugenol 0-7 caspase 9 Homo sapiens 101-110 30518369-7 2018 Real-time PCR was used to study the effect of eugenol on the expression of anti-metastatic genes such as MMP2, MMP9, and TIMP-1, and genes involved in apoptosis including Caspase3, Caspase7, and Caspase9. Eugenol 46-53 caspase 9 Homo sapiens 195-203 30518369-10 2018 Eugenol significantly increased the proportion of MDA-MB-231 and SK-BR-3 cells in late apoptosis and increased the expression of Caspase3, Caspase7, and Caspase9. Eugenol 0-7 caspase 9 Homo sapiens 153-161 25455450-9 2015 Eugenol induced apoptosis through increasing reactive oxygen species (ROS) production, decreasing mitochondrial membrane potential, releasing cytochrome c and activating caspase-9/caspase-3. Eugenol 0-7 caspase 9 Homo sapiens 170-179