PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35504091-6	2022	Eugenol reversed the promoting effect of TNF-alpha on the expression of NF-kappaB signaling pathway-related proteins as well as prostaglandin-endoperoxide synthase 2 (PTGS2, also known as COX-2) protein.	Eugenol	0-7	prostaglandin-endoperoxide synthase 2	Homo sapiens	128-165	
35504091-6	2022	Eugenol reversed the promoting effect of TNF-alpha on the expression of NF-kappaB signaling pathway-related proteins as well as prostaglandin-endoperoxide synthase 2 (PTGS2, also known as COX-2) protein.	Eugenol	0-7	prostaglandin-endoperoxide synthase 2	Homo sapiens	167-172	
31684176-9	2019	Eugenol increased caspase-3 activity and the expression of Bax, cytochrome c (Cyt-c), caspase-3, and caspase-9 and decreased the expression of B-cell lymphoma (Bcl)-2, cyclooxygenase-2 (Cox-2), and interleukin-1 beta (IL-1beta) indicating that eugenol mainly induced cell death by apoptosis.	Eugenol	0-7	prostaglandin-endoperoxide synthase 2	Homo sapiens	168-184	
31684176-9	2019	Eugenol increased caspase-3 activity and the expression of Bax, cytochrome c (Cyt-c), caspase-3, and caspase-9 and decreased the expression of B-cell lymphoma (Bcl)-2, cyclooxygenase-2 (Cox-2), and interleukin-1 beta (IL-1beta) indicating that eugenol mainly induced cell death by apoptosis.	Eugenol	0-7	prostaglandin-endoperoxide synthase 2	Homo sapiens	186-191	
17889685-0	2007	Eugenol modulates cyclooxygenase-2 expression through the activation of nuclear factor kappa B in human osteoblasts.	Eugenol	0-7	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-34	
17889685-5	2007	Furthermore, the eugenol-modulated COX-2 expression was inhibited by an NF-kappaB inhibitor, N-acetylcysteine.	Eugenol	17-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	35-40	
17889685-6	2007	Taken together, eugenol might induce COX-2 expression through the activation of NF-kappaB in human osteoblasts.	Eugenol	16-23	prostaglandin-endoperoxide synthase 2	Homo sapiens	37-42	
12615477-0	2003	Induction of cyclooxygenase-2 mRNA and protein expression by epoxy resin and zinc oxide-eugenol based root canal sealers in human osteoblastic cells.	Eugenol	88-95	prostaglandin-endoperoxide synthase 2	Homo sapiens	13-29	
17889685-4	2007	In addition, COX-2 protein expression in osteoblasts was induced by eugenol in a dose-dependent manner.	Eugenol	68-75	prostaglandin-endoperoxide synthase 2	Homo sapiens	13-18	
16101137-0	2005	Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression by eugenol-related compounds.	Eugenol	94-101	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-74	
17509409-6	2007	Consistent with downregulation of bone-resorbing mediators, eugenol suppressed the messenger RNA expression of LPS-induced IL-1beta, TNF-alpha, and cyclooxygenase-2 in macrophages.	Eugenol	60-67	prostaglandin-endoperoxide synthase 2	Homo sapiens	148-164	
16707845-4	2006	LPS-dependent expression of cyclooxygenase-2 (COX-2) protein was also inhibited markedly by isoeugenol, and less effectively by eugenol.	Eugenol	95-102	prostaglandin-endoperoxide synthase 2	Homo sapiens	28-44	
16707845-4	2006	LPS-dependent expression of cyclooxygenase-2 (COX-2) protein was also inhibited markedly by isoeugenol, and less effectively by eugenol.	Eugenol	95-102	prostaglandin-endoperoxide synthase 2	Homo sapiens	46-51	
16707845-5	2006	Anti-inflammatory action of eugenol compounds may be explained by the inhibition of NO production and COX-2 expression, the pro-inflammatory mediators.	Eugenol	28-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	102-107	
12615477-5	2003	The aim of the present study was to investigate the effects of epoxy resin (AH26) and zinc oxide-eugenol based (Endomethansone and N2) root canal sealers on the expression of COX-2 mRNA gene and protein in cultured human osteoblastic cells.	Eugenol	97-104	prostaglandin-endoperoxide synthase 2	Homo sapiens	175-180	
12444669-5	2002	Of these 49 plant metabolites, eugenol, pyrogallol, and cinnamaldehyde (with IC(50) values of 129, 144, and 245 microM, respectively) were found to inhibit COX-2.	Eugenol	31-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	156-161