PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31684176-9	2019	Eugenol increased caspase-3 activity and the expression of Bax, cytochrome c (Cyt-c), caspase-3, and caspase-9 and decreased the expression of B-cell lymphoma (Bcl)-2, cyclooxygenase-2 (Cox-2), and interleukin-1 beta (IL-1beta) indicating that eugenol mainly induced cell death by apoptosis.	Eugenol	0-7	BCL2 apoptosis regulator	Homo sapiens	143-166	
33509300-13	2021	Combination of DOX with EUG induced apoptosis through the higher BAX/ BCl2 ratio, while with AST was through the increase in caspase 8 expressions.	Eugenol	24-27	BCL2 apoptosis regulator	Homo sapiens	70-74	
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	Eugenol	145-152	BCL2 apoptosis regulator	Homo sapiens	256-260	
23613775-7	2013	We speculated that the mechanism underlying might be that eugenol inhibited the oxidative stress and the activation of ERK1/2, p38MAPK and IKK/NF-kappaB pathways, subsequently inhibited the dissociation of Beclin1-Bcl2 heterodimer and autophagy, and finally impaired IAV replication.	Eugenol	58-65	BCL2 apoptosis regulator	Homo sapiens	214-218	
28915591-7	2017	Furthermore eugenol for external (1 mg) markedly decreased the protein expressions of HER2 (62.9%), AKT (58.6%), PDK1 (56.4%), p85 (54.3%), Bcl2 (59.3%), NF-kappaB (65.7%), Bad (64.0%), Cyclin D1 (43.0%), while p21, p27 and Bax protein expressions were respectively increased 1.83-, 2.52- and 2.51-fold.	Eugenol	12-19	BCL2 apoptosis regulator	Homo sapiens	140-144	
28272477-6	2017	Expression levels of both anti- and pro-apoptotic markers (Bcl-2 and Bax, respectively) decreased with increasing eugenol concentration, with no variation in their relative ratios.	Eugenol	114-121	BCL2 apoptosis regulator	Homo sapiens	59-64	
28272477-7	2017	Eugenol-treated MCF-7 cells overexpressing Bcl-2 exhibited results similar to those of MCF-7.	Eugenol	0-7	BCL2 apoptosis regulator	Homo sapiens	43-48	
28272477-8	2017	Our findings indicate that eugenol toxicity is non-apoptotic Bcl-2 independent, affecting mitochondrial function and plasma membrane integrity with no effect on migration or invasion.	Eugenol	27-34	BCL2 apoptosis regulator	Homo sapiens	61-66	
21382956-7	2012	Furthermore, SFN and eugenol combinations at synergistic dose significantly downregulated the expression of Bcl-2, COX-2 and IL-beta but not the antagonistic combinations.	Eugenol	21-28	BCL2 apoptosis regulator	Homo sapiens	108-113	
35586688-6	2022	Minocycline plus zinc oxide eugenol cement was associated with significantly lower positive rates of HIF-1alpha and Bcl-2 and lower levels of TNF-alpha versus minocycline alone (p < 0.05).	Eugenol	28-35	BCL2 apoptosis regulator	Homo sapiens	116-121	
21939359-9	2011	In addition, the expression analysis of genes involved in apoptosis and inflammation revealed significant downregulation of Bcl-2, COX-2, and IL-1beta on treatment with eugenol.	Eugenol	169-176	BCL2 apoptosis regulator	Homo sapiens	124-129	
19084597-6	2009	Combining 2-ME(2) with eugenol (i) inhibited growth of prostate cancer cells and induced apoptosis at lower concentrations than either single agent alone; (ii) analysis of the data using combination index (CI) showed CI values of 0.4 indicating strong synergistic interaction; (iii) increased population of cells G(2)/M phase by 4.5-fold (p=0.01); (iv) significantly reduced expression of antiapoptotic protein Bcl-2 and enhanced expression of proapoptotic protein Bax.	Eugenol	23-30	BCL2 apoptosis regulator	Homo sapiens	411-416	
15922856-4	2005	We observed that eugenol transduced the apoptotic signal via ROS generation, thereby inducing mitochondrial permeability transition (MPT), reducing anti-apoptotic protein bcl-2 level, inducing cytochrome c release to the cytosol, and subsequent apoptotic cell death.	Eugenol	17-24	BCL2 apoptosis regulator	Homo sapiens	171-176	
34381064-7	2021	RT-qPCR for apoptotic genes (BCL2, CASP3 and CASP8) and necrosis genes (MLKL, RIPK1 and RIPK3) did not show significant differences between control and treated cells of both types, with the exception of eugenol-treated HeLa cells in which expression of BCL2, MLKL and RIPK1 was significantly higher than controls.	Eugenol	203-210	BCL2 apoptosis regulator	Homo sapiens	253-257	
35586688-8	2022	Conclusion: Minocycline plus zinc oxide eugenol cement offers a viable alternative for acute pulpitis as it mitigates the pain of patients, alleviates inflammatory responses, and lowers the positive rate of HIF-1alpha and Bcl-2, so it is worthy of clinical promotion.	Eugenol	40-47	BCL2 apoptosis regulator	Homo sapiens	222-227