PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35504091-0	2022	Eugenol suppresses the proliferation and invasion of TNF-alpha-induced fibroblast-like synoviocytes via regulating NF-kappaB and COX-2.	Eugenol	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134	
35504091-6	2022	Eugenol reversed the promoting effect of TNF-alpha on the expression of NF-kappaB signaling pathway-related proteins as well as prostaglandin-endoperoxide synthase 2 (PTGS2, also known as COX-2) protein.	Eugenol	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193	
35504091-8	2022	In conclusion, eugenol may represent a novel drug to suppress the progression of RA by inhibiting NF-kappaB signaling pathway and COX-2 expression in fibroblast-like synovial cells.	Eugenol	15-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135	
33004893-8	2020	The results of bioinformatics reinforce studies that try to propose eugenol as an anti-inflammatory compound that can act in the COX-2/5-LOX pathways, replacing some NSAIDs in different diseases.	Eugenol	68-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134	
21939359-9	2011	In addition, the expression analysis of genes involved in apoptosis and inflammation revealed significant downregulation of Bcl-2, COX-2, and IL-1beta on treatment with eugenol.	Eugenol	169-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136	
21382956-7	2012	Furthermore, SFN and eugenol combinations at synergistic dose significantly downregulated the expression of Bcl-2, COX-2 and IL-beta but not the antagonistic combinations.	Eugenol	21-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120