PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30518369-0	2018	Anti-metastatic and anti-proliferative activity of eugenol against triple negative and HER2 positive breast cancer cells.	Eugenol	51-58	erb-b2 receptor tyrosine kinase 2	Homo sapiens	87-91	
30518369-9	2018	Eugenol-treated cells showed significantly decreased MMP2 and MMP9 expression and an insignificant increase in TIMP1 expression in HER2 positive and triple negative breast cancer cells.	Eugenol	0-7	erb-b2 receptor tyrosine kinase 2	Homo sapiens	131-135	
28915591-0	2017	Eugenol alleviated breast precancerous lesions through HER2/PI3K-AKT pathway-induced cell apoptosis and S-phase arrest.	Eugenol	0-7	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-59	
28915591-3	2017	In this study, 80 muM eugenol could significantly inhibit the proliferation of HER-2 positive MCF-10AT cells and the inhibition rate was up to 32.8%, but had no obvious inhibitory effect on MCF-7 and MCF-10A cells with HER2 weak expression.	Eugenol	22-29	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-84	
28915591-3	2017	In this study, 80 muM eugenol could significantly inhibit the proliferation of HER-2 positive MCF-10AT cells and the inhibition rate was up to 32.8%, but had no obvious inhibitory effect on MCF-7 and MCF-10A cells with HER2 weak expression.	Eugenol	22-29	erb-b2 receptor tyrosine kinase 2	Homo sapiens	219-223	
28915591-4	2017	Eugenol also significantly induced human breast precancerous lesion MCF-10AT cell apoptosis and cell cycle S-phase arrest, but the biological effects nearly disappeared after HER2 over-expression through transfecting pcDNA3.1-HER2.	Eugenol	0-7	erb-b2 receptor tyrosine kinase 2	Homo sapiens	175-179	
28915591-4	2017	Eugenol also significantly induced human breast precancerous lesion MCF-10AT cell apoptosis and cell cycle S-phase arrest, but the biological effects nearly disappeared after HER2 over-expression through transfecting pcDNA3.1-HER2.	Eugenol	0-7	erb-b2 receptor tyrosine kinase 2	Homo sapiens	226-230	
28915591-7	2017	Furthermore eugenol for external (1 mg) markedly decreased the protein expressions of HER2 (62.9%), AKT (58.6%), PDK1 (56.4%), p85 (54.3%), Bcl2 (59.3%), NF-kappaB (65.7%), Bad (64.0%), Cyclin D1 (43.0%), while p21, p27 and Bax protein expressions were respectively increased 1.83-, 2.52- and 2.51-fold.	Eugenol	12-19	erb-b2 receptor tyrosine kinase 2	Homo sapiens	86-90	
28915591-8	2017	The results showed eugenol could significantly inhibit the development of breast precancerous lesions by blocking HER2/PI3K-AKT signaling network.	Eugenol	19-26	erb-b2 receptor tyrosine kinase 2	Homo sapiens	114-118	
34502165-11	2021	Eugenol is a promising natural anti-cancer agent against triple-negative and HER2-positive breast cancer.	Eugenol	0-7	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-81	
34962586-4	2021	The aim of the study has been on the eugenol compounds, which has potent actions on Eralpha, PR, EGFR, CDK2, mTOR, ERBB2, c-Src, HSP90, and chemokines receptors inhibition.	Eugenol	37-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	115-120