PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34361816-1 2021 Fostamatinib is a prodrug of the active metabolite tamatinib, which is a spleen tyrosine kinase (Syk) inhibitor used in the treatment of primary chronic adult immune thrombocytopenia and rheumatoid arthritis. fostamatinib 0-12 spleen associated tyrosine kinase Rattus norvegicus 73-95 26116555-0 2015 The Syk Inhibitor Fostamatinib Decreases the Severity of Colonic Mucosal Damage in a Rodent Model of Colitis. fostamatinib 18-30 spleen associated tyrosine kinase Rattus norvegicus 4-7 32305129-7 2020 R406, the active metabolite of fostamatinib, a small molecule kinase inhibitor with high selectivity for SYK, inhibited ANCA-induced pro-inflammatory responses in rat leucocytes in vitro. fostamatinib 31-43 spleen associated tyrosine kinase Rattus norvegicus 105-108 34361816-1 2021 Fostamatinib is a prodrug of the active metabolite tamatinib, which is a spleen tyrosine kinase (Syk) inhibitor used in the treatment of primary chronic adult immune thrombocytopenia and rheumatoid arthritis. fostamatinib 0-12 spleen associated tyrosine kinase Rattus norvegicus 97-100 35228550-6 2022 Two-week treatment of sensitized rats with selective SYK inhibitor fostamatinib strongly blocked circulating DSA production without affecting overall total immunoglobulin levels, and inhibition was sustained up to 5 weeks post-completion of the treatment regimen. fostamatinib 67-79 spleen associated tyrosine kinase Rattus norvegicus 53-56