PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19333898-3 2009 Preclinical studies of R-406 or fostamatinib demonstrated a significant reduction in major inflammatory mediators such as TNFalpha, IL-1, IL-6 and IL-18, leading to reduced inflammation and bone degradation in models of RA. fostamatinib 32-44 interleukin 6 Homo sapiens 138-142