PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31431614-2 2019 In this study, we delineate that KRAS-mutant lung cancer cells resistant to pemetrexed (MTA) and anti-MEK drug trametinib acquire an exquisite dependency on endoplasmic reticulum (ER) stress signaling, rendering resistant cancer cells selectively susceptible to blockage of HSP90, the receptor tyrosine kinase AXL, the eukaryotic translation initiation factor 4E (eIF4E), and the unfolded protein response (UPR). trametinib 111-121 ret proto-oncogene Homo sapiens 285-309