PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16880627-4 2006 Serum albumin concentration was time-dependently decreased and correlated well with 3 major biologic determinants of drug clearance, hepatic blood flow (HBF), intrinsic clearance (CL(int)), and the unbound fraction of drugs in plasma (fp) after intravenous administration of cyclophosphamide, tolbutamide, zonisamide, and chlorzoxazone (as probe drugs for low hepatic extraction) and propranolol and lidocaine (as high-hepatic extraction drugs). Zonisamide 306-316 albumin Rattus norvegicus 6-13