PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19429061-1	2009	To clarify the antiepileptic mechanisms of zonisamide (ZNS), we determined the interaction between ZNS and inositol-1,4,5-triphosphate receptor (IP3R) on exocytosis of GABA and glutamate in rat frontal cortex using microdialysis.	Zonisamide	43-53	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	145-149	
19429061-7	2009	In contrast, ZNS inhibited the stimulatory effect of IP3R agonist on K(+)-evoked release.	Zonisamide	13-16	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	53-57	
19429061-9	2009	These results suggest that ZNS-activated N-type VSCC enhances IP3R-associated neurotransmitter release during resting stage, whereas ZNS-induced suppression of P- and L-type VSCCs possibly attenuates IP3R-associated neurotransmitter release during neuronal hyperexcitability.	Zonisamide	27-30	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	62-66	
19429061-9	2009	These results suggest that ZNS-activated N-type VSCC enhances IP3R-associated neurotransmitter release during resting stage, whereas ZNS-induced suppression of P- and L-type VSCCs possibly attenuates IP3R-associated neurotransmitter release during neuronal hyperexcitability.	Zonisamide	27-30	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	200-204	
19429061-10	2009	Therefore, the combination of both of these two actions of ZNS on IP3R-associated neurotransmitter release mechanism seems to be involved, at least in part, in the mechanisms of antiepileptic and neuroprotective actions of ZNS.	Zonisamide	59-62	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	66-70	
19429061-10	2009	Therefore, the combination of both of these two actions of ZNS on IP3R-associated neurotransmitter release mechanism seems to be involved, at least in part, in the mechanisms of antiepileptic and neuroprotective actions of ZNS.	Zonisamide	223-226	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	66-70	
19429061-6	2009	The latter effects of IP3R agonist were weakly enhanced by ZNS, but such stimulatory action of ZNS was abolished by extracellular Ca(2+) depletion.	Zonisamide	59-62	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	22-26