PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24968304-10	2014	These results suggested that nilotinib can inhibit MDM2 and induce a p53-independent apoptosis pathway by downregulating XIAP; thus, nilotinib can treat not only Ph+, but also Ph- ALL patients whose cancer cells overexpress MDM2.	nilotinib	29-38	tumor protein p53	Homo sapiens	69-72	
29370077-0	2018	p53 Gene (NY-CO-13) Levels in Patients with Chronic Myeloid Leukemia: The Role of Imatinib and Nilotinib.	nilotinib	95-104	tumor protein p53	Homo sapiens	0-3	
29370077-5	2018	The purpose of the present study was to evaluate the differential effect of imatinib and nilotinib on p53 gene serum levels in patients with CML.	nilotinib	89-98	tumor protein p53	Homo sapiens	102-105	
29370077-11	2018	CONCLUSIONS: Nilotinib is more effective than imatinib in raising p53 serum levels in patients with chronic myeloid leukemia.	nilotinib	13-22	tumor protein p53	Homo sapiens	66-69	
24968304-10	2014	These results suggested that nilotinib can inhibit MDM2 and induce a p53-independent apoptosis pathway by downregulating XIAP; thus, nilotinib can treat not only Ph+, but also Ph- ALL patients whose cancer cells overexpress MDM2.	nilotinib	133-142	tumor protein p53	Homo sapiens	69-72	
29483845-12	2018	A rescue in the expression of both MLL genes was observed in KCL22S, a CML cell line sensitive to IM, after treatment with dasatinib or nilotinib which was associated with a higher rate of apoptosis, an enhanced expression of p21 (CDKN1A) and a concomitant decrease in the expression of CDK2, CDK4 and Cyclin B1 (CCNB1) in comparison to untreated KCL22S control or IM resistant KCL22R cell line, which suggests involvement of p53 regulated pathway.	nilotinib	136-145	tumor protein p53	Homo sapiens	426-429	
21251937-6	2011	Nilotinib induced apoptosis of HSCs, which was correlated with reduced bcl-2 expression, increased p53 expression, cleavage of PARP, as well as increased expression of PPARgamma and TRAIL-R. Nilotinib also induced cell cycle arrest, accompanied by increased expression of p27 and downregulation of cyclin D1.	nilotinib	0-9	tumor protein p53	Homo sapiens	99-102	
19047160-6	2008	Up-regulated expression of p53/56 Lyn kinase, both at the mRNA and protein level, was found in one of the resistant cell lines and Lyn silencing by small interfering RNA restored sensitivity to nilotinib.	nilotinib	194-203	tumor protein p53	Homo sapiens	27-30