PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27474278-6 2016 The PNIPAAm chains could extend and shrink with different temperature, which suggested that PNIPAAm on the surface of gold nanoparticles could regulate interaction between thrombin and aptamer according to temperature changing. poly-N-isopropylacrylamide 4-11 coagulation factor II, thrombin Homo sapiens 172-180 27474278-6 2016 The PNIPAAm chains could extend and shrink with different temperature, which suggested that PNIPAAm on the surface of gold nanoparticles could regulate interaction between thrombin and aptamer according to temperature changing. poly-N-isopropylacrylamide 92-99 coagulation factor II, thrombin Homo sapiens 172-180 27474278-7 2016 At 25 C, PNIPAAm was hydrophilic extended state, which blocked the interaction between thrombin and aptamer on the surface of gold nanoparticles, therefore thrombin activity had no change. poly-N-isopropylacrylamide 9-16 coagulation factor II, thrombin Homo sapiens 87-95 27474278-7 2016 At 25 C, PNIPAAm was hydrophilic extended state, which blocked the interaction between thrombin and aptamer on the surface of gold nanoparticles, therefore thrombin activity had no change. poly-N-isopropylacrylamide 9-16 coagulation factor II, thrombin Homo sapiens 156-164 27474278-8 2016 On the contrary, at 37 C, PNIPAAm transformed from hydrophilic extended state to hydrophobic shrank state, allowing the aptamer to capture thrombin, inhibiting the activity of thrombin. poly-N-isopropylacrylamide 26-33 coagulation factor II, thrombin Homo sapiens 139-147 27474278-8 2016 On the contrary, at 37 C, PNIPAAm transformed from hydrophilic extended state to hydrophobic shrank state, allowing the aptamer to capture thrombin, inhibiting the activity of thrombin. poly-N-isopropylacrylamide 26-33 coagulation factor II, thrombin Homo sapiens 176-184