PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29430850-1	2018	Efavirenz (EFV), an antiretroviral that interacts clinically with co-administered drugs via activation of the pregnane X receptor (PXR), is extensively metabolized by the cytochromes P450.	efavirenz	11-14	nuclear receptor subfamily 1, group I, member 2	Mus musculus	110-129	
30677459-2	2019	Herein, we investigated the role of pregnane X receptor (PXR) in mediating the adverse effects of efavirenz on lipid homeostasis.	efavirenz	98-107	nuclear receptor subfamily 1, group I, member 2	Mus musculus	36-55	
30677459-2	2019	Herein, we investigated the role of pregnane X receptor (PXR) in mediating the adverse effects of efavirenz on lipid homeostasis.	efavirenz	98-107	nuclear receptor subfamily 1, group I, member 2	Mus musculus	57-60	
30677459-5	2019	RESULTS: We found that efavirenz is a potent PXR-selective agonist that can efficiently activate PXR and induce its target gene expression in vitro and in vivo.	efavirenz	23-32	nuclear receptor subfamily 1, group I, member 2	Mus musculus	45-48	
30677459-5	2019	RESULTS: We found that efavirenz is a potent PXR-selective agonist that can efficiently activate PXR and induce its target gene expression in vitro and in vivo.	efavirenz	23-32	nuclear receptor subfamily 1, group I, member 2	Mus musculus	97-100	
29430850-1	2018	Efavirenz (EFV), an antiretroviral that interacts clinically with co-administered drugs via activation of the pregnane X receptor (PXR), is extensively metabolized by the cytochromes P450.	efavirenz	0-9	nuclear receptor subfamily 1, group I, member 2	Mus musculus	110-129	
29430850-1	2018	Efavirenz (EFV), an antiretroviral that interacts clinically with co-administered drugs via activation of the pregnane X receptor (PXR), is extensively metabolized by the cytochromes P450.	efavirenz	0-9	nuclear receptor subfamily 1, group I, member 2	Mus musculus	131-134	
29430850-1	2018	Efavirenz (EFV), an antiretroviral that interacts clinically with co-administered drugs via activation of the pregnane X receptor (PXR), is extensively metabolized by the cytochromes P450.	efavirenz	11-14	nuclear receptor subfamily 1, group I, member 2	Mus musculus	131-134	
29430850-2	2018	We tested whether its primary metabolite, 8-hydroxyEFV (8-OHEFV) can activate PXR and potentially contribute to PXR-mediated drug-drug interactions attributed to EFV.	efavirenz	51-54	nuclear receptor subfamily 1, group I, member 2	Mus musculus	78-81	
29430850-2	2018	We tested whether its primary metabolite, 8-hydroxyEFV (8-OHEFV) can activate PXR and potentially contribute to PXR-mediated drug-drug interactions attributed to EFV.	efavirenz	51-54	nuclear receptor subfamily 1, group I, member 2	Mus musculus	112-115	
29430850-4	2018	Corroborating this, treatment with EFV for 72 h elevated the mRNA abundance of the PXR target gene, Cyp3a11, by approximately 28-fold in primary hepatocytes isolated from PXR-humanized mice, whereas treatment with 8-OHEFV did not result in a change in Cyp3A11 mRNA levels.	efavirenz	35-38	nuclear receptor subfamily 1, group I, member 2	Mus musculus	83-86	
29430850-4	2018	Corroborating this, treatment with EFV for 72 h elevated the mRNA abundance of the PXR target gene, Cyp3a11, by approximately 28-fold in primary hepatocytes isolated from PXR-humanized mice, whereas treatment with 8-OHEFV did not result in a change in Cyp3A11 mRNA levels.	efavirenz	35-38	nuclear receptor subfamily 1, group I, member 2	Mus musculus	171-174	
29430850-5	2018	FRET-based competitive binding assays and isothermal calorimetry demonstrated that even with the lack of ability to activate PXR, 8-OHEFV displays an affinity for PXR (IC50 12.1 mum; KD 7.9 mum) nearly identical to that of EFV (IC50 18.7 mum; KD 12.5 mum).	efavirenz	134-137	nuclear receptor subfamily 1, group I, member 2	Mus musculus	163-166