PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25485183-3 2014 The GW0742 alcohol derivative was more active than the ester in respect to VDR but less active in regard to PPARdelta. GW0742 4-10 peroxisome proliferator activated receptor delta Homo sapiens 108-117 24939361-0 2014 The PPARbeta/delta agonist GW0742 modulates signaling pathways associated with cardiac myocyte growth via a non-genomic redox mechanism. GW0742 27-33 peroxisome proliferator activated receptor delta Homo sapiens 4-12 24939361-5 2014 The selective PPARbeta/delta agonist GW0742 attenuated ERK1/2 and Akt phosphorylation that was stimulated by growth promoting agonists (phenylephrine, insulin or IGF-1). GW0742 37-43 peroxisome proliferator activated receptor delta Homo sapiens 14-22 24352213-4 2014 In the HMC, both GW0742, an authentic PPAR-delta agonist, and telmisartan enhanced PPAR response element (PPRE)-luciferase activity dose dependently, and these increases were blunted by GSK0660, a specific PPAR-delta antagonist, but not by GW9662, a PPAR-gamma antagonist. GW0742 17-23 peroxisome proliferator activated receptor delta Homo sapiens 38-48 24352213-4 2014 In the HMC, both GW0742, an authentic PPAR-delta agonist, and telmisartan enhanced PPAR response element (PPRE)-luciferase activity dose dependently, and these increases were blunted by GSK0660, a specific PPAR-delta antagonist, but not by GW9662, a PPAR-gamma antagonist. GW0742 17-23 peroxisome proliferator activated receptor delta Homo sapiens 206-216 24486703-7 2014 However, activation of the PPARdelta signaling pathway by the agonist GW0742 reversed all these changes induced by Hcy. GW0742 70-76 peroxisome proliferator activated receptor delta Homo sapiens 27-36 25485183-0 2014 Modulation of Transcription mediated by the Vitamin D Receptor and the Peroxisome Proliferator-Activated Receptor delta in the presence of GW0742 analogs. GW0742 139-145 peroxisome proliferator activated receptor delta Homo sapiens 71-119 24294133-3 2013 PANC-1 cells cultured in RPMI-1640 were exposed to the commonly used ERK1/2 pathway inhibitor PD98059 and PPAR delta agonist GW0742. GW0742 125-131 peroxisome proliferator activated receptor delta Homo sapiens 106-116 23943160-4 2013 We found that when activated with the highly selective PPARbeta/delta agonists, GW0742 and GW501516, PPARbeta/delta inhibited the proliferation and markedly induced the apoptosis of three endometrial cancer cell lines. GW0742 80-86 peroxisome proliferator activated receptor delta Homo sapiens 55-63 23943160-4 2013 We found that when activated with the highly selective PPARbeta/delta agonists, GW0742 and GW501516, PPARbeta/delta inhibited the proliferation and markedly induced the apoptosis of three endometrial cancer cell lines. GW0742 80-86 peroxisome proliferator activated receptor delta Homo sapiens 101-109 21426320-2 2011 EXPERIMENTAL APPROACH: Human PPARdelta function in lipid metabolism was assessed at baseline, after fasting or when challenged with the GW0742 compound in mice fed a chow diet or high-fat diet (HFD). GW0742 136-142 peroxisome proliferator activated receptor delta Homo sapiens 29-38 23915387-3 2013 OBJECTIVES: In this study, we investigated the effects of GW-0742, a synthetic high-affinity PPAR-beta/delta agonist, on neointimal hyperplasia after arterial injury. GW0742 58-65 peroxisome proliferator activated receptor delta Homo sapiens 93-102 22945906-8 2013 Induction of HO-1 by peroxisome proliferator-activated receptor delta agonist (GW0742) prevented the effect of nicotine. GW0742 79-85 peroxisome proliferator activated receptor delta Homo sapiens 21-69 22977012-0 2012 Detection of PPARdelta agonists GW1516 and GW0742 and their metabolites in human urine. GW0742 43-49 peroxisome proliferator activated receptor delta Homo sapiens 13-22 22977012-2 2012 To simulate the metabolism of PPARdelta agonist GW0742, in vitro reactions were performed which demonstrated that the main metabolic pathway is oxidation of the acyclic divalent sulfur to give the respective sulfoxide and sulfone. GW0742 48-54 peroxisome proliferator activated receptor delta Homo sapiens 30-39 22606221-4 2012 GW0742 is a synthetic ligand that binds PPARdelta more than 300-fold more tightly than PPARalpha or PPARgamma but the structural basis of PPARdelta:GW0742 interactions and reasons for strong selectivity are not clear. GW0742 0-6 peroxisome proliferator activated receptor delta Homo sapiens 40-49 22606221-4 2012 GW0742 is a synthetic ligand that binds PPARdelta more than 300-fold more tightly than PPARalpha or PPARgamma but the structural basis of PPARdelta:GW0742 interactions and reasons for strong selectivity are not clear. GW0742 0-6 peroxisome proliferator activated receptor delta Homo sapiens 138-147 22606221-5 2012 Here we report the crystal structure of the PPARdelta:GW0742 complex. GW0742 54-60 peroxisome proliferator activated receptor delta Homo sapiens 44-53 22606221-6 2012 Comparisons of the PPARdelta:GW0742 complex with published structures of PPARs in complex with alpha and gamma selective agonists and pan agonists suggests that two residues (Val312 and Ile328) in the buried hormone binding pocket play special roles in PPARdelta selective binding and experimental and computational analysis of effects of mutations in these residues confirms this and suggests that bulky substituents that line the PPARalpha and gamma ligand binding pockets as structural barriers for GW0742 binding. GW0742 29-35 peroxisome proliferator activated receptor delta Homo sapiens 19-28 22606221-6 2012 Comparisons of the PPARdelta:GW0742 complex with published structures of PPARs in complex with alpha and gamma selective agonists and pan agonists suggests that two residues (Val312 and Ile328) in the buried hormone binding pocket play special roles in PPARdelta selective binding and experimental and computational analysis of effects of mutations in these residues confirms this and suggests that bulky substituents that line the PPARalpha and gamma ligand binding pockets as structural barriers for GW0742 binding. GW0742 29-35 peroxisome proliferator activated receptor delta Homo sapiens 253-262 22606221-6 2012 Comparisons of the PPARdelta:GW0742 complex with published structures of PPARs in complex with alpha and gamma selective agonists and pan agonists suggests that two residues (Val312 and Ile328) in the buried hormone binding pocket play special roles in PPARdelta selective binding and experimental and computational analysis of effects of mutations in these residues confirms this and suggests that bulky substituents that line the PPARalpha and gamma ligand binding pockets as structural barriers for GW0742 binding. GW0742 502-508 peroxisome proliferator activated receptor delta Homo sapiens 19-28 19906781-9 2010 In human umbilical vein endothelial cells, L-165041 and GW0742 increased nitric oxide (NO) production and Akt and endothelial NOS (eNOS) phosphorylation, which were sensitive to PI3K inhibition and PPAR-beta blockade. GW0742 56-62 peroxisome proliferator activated receptor delta Homo sapiens 198-207 20066433-5 2010 Specific pharmacological activation of PPARbeta using GW0742 or GW501516 in low concentrations inhibits proliferation of human and murine melanoma cells. GW0742 54-60 peroxisome proliferator activated receptor delta Homo sapiens 39-47 18337495-4 2008 In this model, administration of the PPARdelta agonist GW0742 (1 or 10 mg/kg) substantially attenuated AngII-accelerated atherosclerosis without altering blood pressure and increased vascular expression of Bcl-6, RGS4, and RGS5, which was associated with suppression of inflammatory and atherogenic gene expression in the artery. GW0742 55-61 peroxisome proliferator activated receptor delta Homo sapiens 37-46 18687807-9 2008 Although inhibition of keratinocyte proliferation by GW0742 was PPARbeta/delta-dependent, inhibition of cell proliferation by RA occurred in both genotypes. GW0742 53-59 peroxisome proliferator activated receptor delta Homo sapiens 64-72 18054822-5 2008 Culturing cells in the presence of either GW0742 or GW501516 caused upregulation of the known PPARbeta/delta target gene angiopoietin-like protein 4 (ANGPTL4). GW0742 42-48 peroxisome proliferator activated receptor delta Homo sapiens 94-102 18003597-4 2008 Ethanol (20 mM) reduced the potency of the PPARbeta ligand GW0742, evident by a rightward shift in the GW0742 dose-response curve, whereas for PPARalpha activation by GW7647, ethanol mediated its effects primarily through reducing efficacy as evidenced by a reduction in maximal response. GW0742 59-65 peroxisome proliferator activated receptor delta Homo sapiens 43-51 18003597-4 2008 Ethanol (20 mM) reduced the potency of the PPARbeta ligand GW0742, evident by a rightward shift in the GW0742 dose-response curve, whereas for PPARalpha activation by GW7647, ethanol mediated its effects primarily through reducing efficacy as evidenced by a reduction in maximal response. GW0742 103-109 peroxisome proliferator activated receptor delta Homo sapiens 43-51 18048767-6 2008 Chromatin immunoprecipitation assays showed that GW0742 switched the association of BCL-6, a transcription repressor, from PPAR-delta to the vascular cell adhesion molecule (VCAM)-1 promoter. GW0742 49-55 peroxisome proliferator activated receptor delta Homo sapiens 123-133 15793256-4 2005 Specific activation of PPARdelta using two pharmacological agonists (GW501516 and GW0742) increased glucose uptake independently of insulin in differentiated C2C12 myotubes. GW0742 82-88 peroxisome proliferator activated receptor delta Homo sapiens 23-32 17254750-5 2007 Ligand activation of PPARbeta/delta with GW0742 prevented cell cycle progression from G1 to S phase and attenuated cell proliferation in N/TERT-1 cells. GW0742 41-47 peroxisome proliferator activated receptor delta Homo sapiens 21-29 16239641-6 2006 The effects of treprostinil sodium on human lung cell proliferation are mimicked by those of the highly selective PPARbeta ligand GW0742. GW0742 130-136 peroxisome proliferator activated receptor delta Homo sapiens 114-122 33426208-2 2020 Previous study has reported that mixture of GW0742 (PPAR-delta agonist), hyaluronic acid (HA) and mesenchymal stem cells (MSCs) enhance chondrogenesis. GW0742 44-50 peroxisome proliferator activated receptor delta Homo sapiens 52-62 34387896-11 2022 Accordingly, pretreatment of LPS treated HepG2 cells with the PPARdelta agonist GW0742, suppressed mRNA expression of inflammatory markers. GW0742 80-86 peroxisome proliferator activated receptor delta Homo sapiens 62-71 12699745-3 2003 Optimization of these hits by structure-guided design led to 7k (GW501516) and 7l (GW0742), which shows an EC(50) of 1.1 nM against PPARdelta with 1000-fold selectivity over the other human subtypes. GW0742 83-89 peroxisome proliferator activated receptor delta Homo sapiens 132-141 29621036-6 2018 The known PPAR-delta agonists, GW1516, L165041, and GW0742, showed potent agonist activity against human, mouse, and rat receptors (ranging from 165- to 396-fold). GW0742 52-58 peroxisome proliferator activated receptor delta Homo sapiens 10-20 29208022-1 2017 BACKGROUND: We tested whether GW0742, a peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) agonist, improves endothelial dysfunction induced by plasma from patients with systemic lupus erythematosus (SLE) involving the inhibition of endoplasmic reticulum (ER) stress. GW0742 30-36 peroxisome proliferator activated receptor delta Homo sapiens 40-93 29287957-6 2018 GW0742 is a PPARdelta agonist previously identified by our group as a VDR antagonist. GW0742 0-6 peroxisome proliferator activated receptor delta Homo sapiens 12-21 29208022-1 2017 BACKGROUND: We tested whether GW0742, a peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) agonist, improves endothelial dysfunction induced by plasma from patients with systemic lupus erythematosus (SLE) involving the inhibition of endoplasmic reticulum (ER) stress. GW0742 30-36 peroxisome proliferator activated receptor delta Homo sapiens 95-103 28901183-9 2017 GW0742, a PPAR-delta agonist, greatly enhanced MSC chondrogenesis and the expression of type II collagen and glycosaminoglycan (GAG) in hBM-MSC-derived chondrocytes. GW0742 0-6 peroxisome proliferator activated receptor delta Homo sapiens 10-20 28825467-1 2017 We describe the parallel synthesis of novel analogs of GW0742, a peroxisome proliferator-activated receptor delta (PPARdelta) agonist. GW0742 55-61 peroxisome proliferator activated receptor delta Homo sapiens 65-113 28825467-1 2017 We describe the parallel synthesis of novel analogs of GW0742, a peroxisome proliferator-activated receptor delta (PPARdelta) agonist. GW0742 55-61 peroxisome proliferator activated receptor delta Homo sapiens 115-124 28825467-5 2017 We identified many potent PPARdelta agonists that were less toxic than GW0742, where ~65 of the compounds synthesized exhibited partial PPARdelta activity (23-98%) with EC50 values ranging from 0.007-18.2 muM. GW0742 71-77 peroxisome proliferator activated receptor delta Homo sapiens 26-35 28825467-5 2017 We identified many potent PPARdelta agonists that were less toxic than GW0742, where ~65 of the compounds synthesized exhibited partial PPARdelta activity (23-98%) with EC50 values ranging from 0.007-18.2 muM. GW0742 71-77 peroxisome proliferator activated receptor delta Homo sapiens 136-145 26206209-0 2016 The PPARbeta/delta Agonist GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons: Role of PPARbeta/delta in Neuronal Maturation. GW0742 27-33 peroxisome proliferator activated receptor delta Homo sapiens 4-12 26206209-0 2016 The PPARbeta/delta Agonist GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons: Role of PPARbeta/delta in Neuronal Maturation. GW0742 27-33 peroxisome proliferator activated receptor delta Homo sapiens 110-118 26206209-4 2016 To get more insight into the molecular mechanism by which PPARbeta/delta may be involved in neuronal maturation processes, in this work a specific PPARbeta/delta agonist, GW0742 was used administered alone or in association with a specific PPARbeta/delta antagonist, the GSK0660, and the parameters involved in neuronal differentiation and maturation were assayed. GW0742 171-177 peroxisome proliferator activated receptor delta Homo sapiens 147-155 26206209-4 2016 To get more insight into the molecular mechanism by which PPARbeta/delta may be involved in neuronal maturation processes, in this work a specific PPARbeta/delta agonist, GW0742 was used administered alone or in association with a specific PPARbeta/delta antagonist, the GSK0660, and the parameters involved in neuronal differentiation and maturation were assayed. GW0742 171-177 peroxisome proliferator activated receptor delta Homo sapiens 147-155 26768366-3 2016 C2C12 myoblasts treated with a PPARbeta/delta agonist, GW0742 exhibit enhanced myotube formation and muscle-specific gene expression. GW0742 55-61 peroxisome proliferator activated receptor delta Homo sapiens 31-39