PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29925480-0	2018	Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid.	chelerythrine	47-60	monoamine oxidase A	Homo sapiens	24-43	
29925480-1	2018	Chelerythrine, an isoquinoline alkaloid isolated from the herbaceous perennial Chelidonium majus, was found to potently and selectively inhibit an isoform of recombinant human monoamine oxidase-A (MAO-A) with an IC50 value of 0.55 microM.	chelerythrine	0-13	monoamine oxidase A	Homo sapiens	176-195	
29925480-1	2018	Chelerythrine, an isoquinoline alkaloid isolated from the herbaceous perennial Chelidonium majus, was found to potently and selectively inhibit an isoform of recombinant human monoamine oxidase-A (MAO-A) with an IC50 value of 0.55 microM.	chelerythrine	0-13	monoamine oxidase A	Homo sapiens	197-202	
29925480-2	2018	Chelerythrine was a reversible competitive MAO-A inhibitor (Ki = 0.22 microM) with a potency much greater than toloxatone (IC50 = 1.10 microM), a marketed drug.	chelerythrine	0-13	monoamine oxidase A	Homo sapiens	43-48	
29925480-4	2018	A structural comparison with corynoline suggested the 1- and/or 2-methoxy groups of chelerythrine increase its inhibitory activity against MAO-A.	chelerythrine	84-97	monoamine oxidase A	Homo sapiens	139-144	
29925480-5	2018	Molecular docking simulations revealed that the binding affinity of chelerythrine for MAO-A (-9.7 kcal/mol) was greater than that for MAO-B (-4.6 kcal/mol).	chelerythrine	68-81	monoamine oxidase A	Homo sapiens	86-91	
29925480-6	2018	Docking simulation implied that Cys323 and Tyr444 of MAO-A are key residues for hydrogen-bond interaction with chelerythrine.	chelerythrine	111-124	monoamine oxidase A	Homo sapiens	53-58	
29925480-7	2018	Our findings suggest chelerythrine is one of the most reversible selective and potent natural inhibitor of MAO-A, and that it be regarded a potential lead compound for the design of novel reversible MAO-A inhibitors.	chelerythrine	21-34	monoamine oxidase A	Homo sapiens	107-112	
29925480-7	2018	Our findings suggest chelerythrine is one of the most reversible selective and potent natural inhibitor of MAO-A, and that it be regarded a potential lead compound for the design of novel reversible MAO-A inhibitors.	chelerythrine	21-34	monoamine oxidase A	Homo sapiens	199-204