PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30377685-5 2018 The results showed that the effects of icaritin on the proliferation and apoptosis of MG63 cells were significantly decreased after ERalpha36 knockdown, and icaritin could up-regulate the levels of ERK and AKT phosphorylation in MG63 cells, which could be reduced by ERalpha36 knockdown. icaritin 157-165 AKT serine/threonine kinase 1 Homo sapiens 206-209 33645069-1 2021 Based on the PI3K/Akt signaling pathway, this study aimed to observe the proliferation and apoptosis of ovarian cancer SKOV3 cells at different concentrations of icaritin, in order to explore the possible molecular mechanisms. icaritin 162-170 AKT serine/threonine kinase 1 Homo sapiens 18-21 33645069-16 2021 The gene expressions of PI3K and Akt in icaritin groups were down-regulated(P<0.05). icaritin 40-48 AKT serine/threonine kinase 1 Homo sapiens 33-36 33645069-17 2021 The protein expression of PI3K and p-Akt in icaritin groups were reduced(P<0.05). icaritin 44-52 AKT serine/threonine kinase 1 Homo sapiens 37-40 32256768-9 2020 Furthermore, icaritin treatment increased the expression of estrogen receptor (ER)beta and the phosphatase and tensin (PTEN) homolog oncoprotein, thus reducing the expression of downstream targets of PTEN; protein kinase B (Akt) and phosphorylated Akt. icaritin 13-21 AKT serine/threonine kinase 1 Homo sapiens 224-227 32256768-9 2020 Furthermore, icaritin treatment increased the expression of estrogen receptor (ER)beta and the phosphatase and tensin (PTEN) homolog oncoprotein, thus reducing the expression of downstream targets of PTEN; protein kinase B (Akt) and phosphorylated Akt. icaritin 13-21 AKT serine/threonine kinase 1 Homo sapiens 248-251 31032347-7 2019 The proved underlying mechanisms of the cytotoxic effects of icaritin are different in various cell types of hematological malignancies but associated with the critical cell signal pathway, including PI3K/Akt, JAK/STAT3, and MAPK/ERK/JNK. icaritin 61-69 AKT serine/threonine kinase 1 Homo sapiens 205-208 32598859-4 2020 While its exact antitumor mechanisms await revelation, icaritin has been found to regulate several key molecules and pathways concerning cell fate, including CDK-dependent pathways, mitogen-activated protein kinases (MAPKs), the serine-threonine kinase AKT, signal transducer and activator of transcription 3 (STAT3), and p53. icaritin 55-63 AKT serine/threonine kinase 1 Homo sapiens 253-256 31829310-0 2019 Down-regulation of microRNA-10a mediates the anti-tumor effect of icaritin in A549 cells via the PTEN/AKT and ERK pathway. icaritin 66-74 AKT serine/threonine kinase 1 Homo sapiens 102-105 31829310-7 2019 Furthermore, we found that the regulation of miR-10a in the anti-tumor effects of icaritin was mediated via the PTEN/AKT/ERK pathway by directly targeting to PTEN. icaritin 82-90 AKT serine/threonine kinase 1 Homo sapiens 117-120 30377685-6 2018 The effect of icaritin on the proliferation of MG63 cells was significantly decreased by pretreating the cells with U0126 (an ERK signaling pathway blocker) and LY294002 (an AKT signaling pathway blocker), respectively. icaritin 14-22 AKT serine/threonine kinase 1 Homo sapiens 174-177 30377685-8 2018 These results suggest that icaritin exerts proliferation promotion and anti-apoptosis effects on osteoblasts through ERalpha36 and its downstream ERK and AKT signaling pathways. icaritin 27-35 AKT serine/threonine kinase 1 Homo sapiens 154-157 29625193-0 2018 Icaritin induces ovarian cancer cell apoptosis through activation of p53 and inhibition of Akt/mTOR pathway. icaritin 0-8 AKT serine/threonine kinase 1 Homo sapiens 91-94 29625193-9 2018 The icaritin-induced OC cell apoptosis may be associated with the activation of p53 and the suppression of Akt/mTOR pathway. icaritin 4-12 AKT serine/threonine kinase 1 Homo sapiens 107-110 24333105-0 2014 Icaritin attenuates cigarette smoke-mediated oxidative stress in human lung epithelial cells via activation of PI3K-AKT and Nrf2 signaling. icaritin 0-8 AKT serine/threonine kinase 1 Homo sapiens 116-119 26356761-0 2015 Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1alpha signalling. icaritin 0-8 AKT serine/threonine kinase 1 Homo sapiens 124-127 26356761-5 2015 Furthermore, the findings strongly indicate that the modulatory effect of icaritin on EMMPRIN is mediated via the PTEN/Akt/HIF-1alpha signalling pathway. icaritin 74-82 AKT serine/threonine kinase 1 Homo sapiens 119-122 25887673-11 2015 The anti-proliferative and pro-apoptotic effects of Icaritin are likely mediated by inhibition of Stat3 and Akt pathways through LMP1 downregulation. icaritin 52-60 AKT serine/threonine kinase 1 Homo sapiens 108-111 23550021-0 2013 Icaritin induces AML cell apoptosis via the MAPK/ERK and PI3K/AKT signal pathways. icaritin 0-8 AKT serine/threonine kinase 1 Homo sapiens 62-65 23550021-7 2013 Icaritin downregulates p-ERK and p-AKT and inhibits the expression of c-myc. icaritin 0-8 AKT serine/threonine kinase 1 Homo sapiens 35-38 23550021-9 2013 The underlying mechanisms of icaritin anti-AML activity are associated with inhibition of the MAPK/ERK and PI3K/AKT signals and downregulation of c-myc. icaritin 29-37 AKT serine/threonine kinase 1 Homo sapiens 112-115 21887305-0 2011 Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings. icaritin 0-8 AKT serine/threonine kinase 1 Homo sapiens 137-140 21887305-9 2011 Icaritin could up-regulate phospho-JNK or phospho-C-Jun and down-regulate phospho-ERK, phospho-P-38, Jak-2, phospho-Stat3 and phospho-Akt expression with dose- or time-dependent manner. icaritin 0-8 AKT serine/threonine kinase 1 Homo sapiens 134-137 34147477-6 2021 Under basal conditions of astrocytes, icariin and icaritin treatment alone increased the phosphorylation of ERK1/2 and AKT, which could be blocked by JB-1. icaritin 50-58 AKT serine/threonine kinase 1 Homo sapiens 119-122 35433438-0 2022 Icaritin Inhibits Migration and Invasion of Human Ovarian Cancer Cells via the Akt/mTOR Signaling Pathway. icaritin 0-8 AKT serine/threonine kinase 1 Homo sapiens 79-82 35433438-5 2022 Mechanistically, icaritin at 20 muM significantly inhibited the phosphorylation of Akt and mTOR, as well as decreased the expression of vimentin and increased the expression of E-cadherin. icaritin 17-25 AKT serine/threonine kinase 1 Homo sapiens 83-86 35433438-6 2022 Our data indicate that icaritin, a prenylated flavonoid natural product, could serve as a potential inhibitor of cisplatin-resistant OC by inhibiting the Akt/mTOR signaling pathway. icaritin 23-31 AKT serine/threonine kinase 1 Homo sapiens 154-157