PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24324713-4	2013	Icaritin inhibited both constitutive and IL-6-induced phospho-STAT3 (STAT3(Y705)) and reduced the level of STAT3-regulated proteins Bcl-xL, Mcl-1, Survivin, and CyclinD1 in a dose-dependent manner.	icaritin	0-8	cyclin D1	Homo sapiens	161-169	
28529129-7	2017	We also found that icaritin inhibited ER-alpha36-mediated MAPK/ERK pathway and cyclin D1 induction by estrogen.	icaritin	19-27	cyclin D1	Homo sapiens	79-88	
19876716-9	2010	Consistent with growth inhibition and apoptosis induction, icaritin decreased cyclin D1 and CDK4 expression and increased Bax/Bcl-2 ratio in human PSMCs.	icaritin	59-67	cyclin D1	Homo sapiens	78-87	
17382317-10	2007	Consistently with G(1) arrest, icaritin increased protein expressions of pRb, p27(Kip1) and p16(Ink4a), while showed decrease in phosphorylated pRb, Cyclin D1 and CDK4.	icaritin	31-39	cyclin D1	Homo sapiens	149-158	
21408143-3	2011	Icaritin-inhibited cell growth was associated with increased levels of p21 and p27 expression and reduced cyclinD1 and cdk 4 expression.	icaritin	0-8	cyclin D1	Homo sapiens	106-114