PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29625193-7 2018 Icaritin induced OC cell apoptosis in vitro, as indicated by the increase of Annexin V+/PI+ apoptotic cells analyzed with flow cytometry, and the cleavage of caspase 9, caspase 3 and poly-ADP-ribose polymerase (PARP) detected with western blotting. icaritin 0-8 caspase 9 Homo sapiens 158-167 25887673-10 2015 Additionally, Icaritin upregulates Bax, downregulates Bcl-2 and pBad, and activates caspase-3 and caspase-9. icaritin 14-22 caspase 9 Homo sapiens 98-107 24608674-9 2014 Moreover, icaritin (5 mumol/L) time-dependently induced the apoptosis of SaOS2 cells, markedly suppressed MMP-2 and MMP-9 expression, upregulated caspase-3 and caspase-9 expression, and increased the level of cleaved caspase-3 in the cells. icaritin 10-18 caspase 9 Homo sapiens 160-169 24895574-4 2014 We further found that icaritin could significantly inhibit Raji cells proliferation with S-phase arrest of cell cycle and induced cell apoptosis accompanied by activation of caspase-8 and caspase-9 and cleavage of PARP. icaritin 22-30 caspase 9 Homo sapiens 188-197 23550021-6 2013 Icaritin induced activation of caspase-9, -3, -7 and the cleavage of PARP as measured by Western blotting. icaritin 0-8 caspase 9 Homo sapiens 31-40