PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34540000-0	2021	Icaritin induces cellular senescence by accumulating the ROS production and regulation of the Jak2/Stat3/p21 pathway in imatinib-resistant, chronic myeloid leukemia cells.	icaritin	0-8	Janus kinase 2	Homo sapiens	94-98	
21887305-0	2011	Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings.	icaritin	0-8	Janus kinase 2	Homo sapiens	125-129	
21887305-9	2011	Icaritin could up-regulate phospho-JNK or phospho-C-Jun and down-regulate phospho-ERK, phospho-P-38, Jak-2, phospho-Stat3 and phospho-Akt expression with dose- or time-dependent manner.	icaritin	0-8	Janus kinase 2	Homo sapiens	101-106	
34765550-0	2021	Icaritin-Induced FAM99A Affects GLUT1-Mediated Glycolysis via Regulating the JAK2/STAT3 Pathway in Hepatocellular Carcinoma.	icaritin	0-8	Janus kinase 2	Homo sapiens	77-81	
34765550-4	2021	It has also been demonstrated that the JAK2/STAT3 pathway is related to HCC and is the target of icaritin treatment.	icaritin	97-105	Janus kinase 2	Homo sapiens	39-43	
34765550-6	2021	Our study aimed to clarify the mechanisms underlying glycolysis and understand the regulating effects of the FAM99A and JAK2/STAT3 pathway in HCC cells in icaritin treatment.	icaritin	155-163	Janus kinase 2	Homo sapiens	120-124	
34765550-12	2021	Overall, our study proved that icaritin-induced FAM99A can inhibit HCC cell viability and GLUT1-mediated glycolysis via blocking the JAK2/STAT3 pathway.	icaritin	31-39	Janus kinase 2	Homo sapiens	133-137	
34540000-8	2021	The results showed that icaritin inhibited cell growth and induced cell senescence in imatinib-resistant CML cells, which is associated with the regulation of the JAK2/STAT3/P21 axis and accompanied by the accumulation of ROS.	icaritin	24-32	Janus kinase 2	Homo sapiens	163-167	
26376676-0	2015	A novel anti-cancer agent Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway.	icaritin	26-34	Janus kinase 2	Homo sapiens	120-124	
26376676-5	2015	We also found that Icaritin reduced expression of Interleukin-6 Receptors (IL-6Rs), attenuated both constitutive and IL-6-induced phosphorylation of Janus-activated kinases 2 (Jak2) and Signal transducer and activator of transcription 3 (Stat3), and inhibited Stat3 downstream genes, such as Bmi-1 and Oct4.	icaritin	19-27	Janus kinase 2	Homo sapiens	149-174	
26376676-5	2015	We also found that Icaritin reduced expression of Interleukin-6 Receptors (IL-6Rs), attenuated both constitutive and IL-6-induced phosphorylation of Janus-activated kinases 2 (Jak2) and Signal transducer and activator of transcription 3 (Stat3), and inhibited Stat3 downstream genes, such as Bmi-1 and Oct4.	icaritin	19-27	Janus kinase 2	Homo sapiens	176-180	
24324713-5	2013	Icaritin also inhibited activation of Janus-activated kinase-2 (JAK2), while it showed minimal effects on the activation of other key signaling pathways, including AKT and MAPK.	icaritin	0-8	Janus kinase 2	Homo sapiens	38-62	
24324713-5	2013	Icaritin also inhibited activation of Janus-activated kinase-2 (JAK2), while it showed minimal effects on the activation of other key signaling pathways, including AKT and MAPK.	icaritin	0-8	Janus kinase 2	Homo sapiens	64-68