PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11678058-5	2001	A review of recent literature suggests that clarithromycin may induce digoxin toxicity by three different mechanisms, including reduction of renal excretion of digoxin, alteration of intestinal flora, and inhibition of cytochrome P-450 in the liver.	Clarithromycin	44-58	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	219-235	
9935275-11	1999	Clarithromycin is a weak inducer of CYP and exhibits fewer drug-drug interactions than erythromycin.	Clarithromycin	0-14	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	36-39	
10997945-4	2000	Other cytochrome P450 (CYP) 3A4 inhibitors, cimetidine, erythromycin, and clarithromycin, also inhibited the metabolism of cisapride and mosapride.	Clarithromycin	74-88	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	6-21	
11720625-3	1999	However, clarithromycin is thought to be less frequently associated with drug induced TdP, because it inactivates hepatic cytochrome P-450 to a lesser extent than erythromycin.	Clarithromycin	9-23	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	122-138	
31656654-3	2019	The cytochrome P450 (CYP) enzyme inducer, rifampicin, and the CYP inhibitor, clarithromycin, have clinical activity against MAC and key drugs in the treatment of MAC infection.	Clarithromycin	77-91	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	62-65