PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26190895-8 2015 RESULTS: Clarithromycin significantly induced transcription of ULBP2 and ADAM17 in both A549 and LCSC #2 cells, which endogenously express minimal and abundant levels of ULBP2, respectively. Clarithromycin 9-23 ADAM metallopeptidase domain 17 Rattus norvegicus 73-79 26190895-12 2015 Finally, clarithromycin significantly inhibited the activity of ADAM17 in LCSC #2 cells. Clarithromycin 9-23 ADAM metallopeptidase domain 17 Rattus norvegicus 64-70 26190895-13 2015 CONCLUSION: These findings suggest that clarithromycin induces ULBP2 expression and reduces the amount of sULBP2, by possibly inhibiting the activity of the potent ULBP2-shedding enzyme ADAM17. Clarithromycin 40-54 ADAM metallopeptidase domain 17 Rattus norvegicus 186-192