PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34013847-3 2021 The plasma concentrations ratios of alpha-hydroxytriazolam and 4-hydroxytriazolam to triazolam in portal blood were significantly decreased by multiple administration of clarithromycin in CYP3A-humanised mice.These results suggest that intestinal CYP3A activity was inhibited by macrolide antibiotics in CYP3A-humanised mice in vitro and in vivo. Clarithromycin 170-184 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 188-193 34013847-3 2021 The plasma concentrations ratios of alpha-hydroxytriazolam and 4-hydroxytriazolam to triazolam in portal blood were significantly decreased by multiple administration of clarithromycin in CYP3A-humanised mice.These results suggest that intestinal CYP3A activity was inhibited by macrolide antibiotics in CYP3A-humanised mice in vitro and in vivo. Clarithromycin 170-184 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 247-252 34013847-3 2021 The plasma concentrations ratios of alpha-hydroxytriazolam and 4-hydroxytriazolam to triazolam in portal blood were significantly decreased by multiple administration of clarithromycin in CYP3A-humanised mice.These results suggest that intestinal CYP3A activity was inhibited by macrolide antibiotics in CYP3A-humanised mice in vitro and in vivo. Clarithromycin 170-184 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 247-252