PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15203552-14	2004	CONCLUSIONS: The beneficial effect of the prolonged treatment of CF patients with a 14-membered ring macrolide antibiotic clarithromycin seems to be associated not only with down-regulation of the inflammatory response, but also with immunological changes including the switch from Th2 to Th1 type response.	Clarithromycin	122-136	negative elongation factor complex member C/D	Homo sapiens	289-292	
16006447-10	2005	There was no change in the Th1/Th2 ratio for moxifloxacin or ciprofloxacin, but the Th1/Th2 ratio increased with increasing concentrations of clarithromycin, from a median [range] of 5.3 [1.3--16.0] without antibiotic to 9.1 [1.8--18.8] at 125 mg/L (P=0.017).	Clarithromycin	142-156	negative elongation factor complex member C/D	Homo sapiens	84-87	
16006447-12	2005	However, clarithromycin decreased only interleukin-4 expression such that the Th1/Th2 ratio increased.	Clarithromycin	9-23	negative elongation factor complex member C/D	Homo sapiens	78-81	
11814768-1	2002	The effect of the macrolide antibiotics, clarithromycin, midecamycin acetate and josamycin, on the generation of Th1- and Th2-type cytokines by mitogen-stimulated human T lymphocytes was compared with that of fosfomycin.	Clarithromycin	41-55	negative elongation factor complex member C/D	Homo sapiens	113-116