PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21682551-6	2011	Pitavastatin has a distinctive metabolic profile that means it is marginally metabolised by CYP enzymes, and is therefore expected to have a low risk of DDIs and related ADRs.	pitavastatin	0-12	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	92-95	
26104032-2	2015	Pharmacokinetic studies show that pitavastatin is carried into the liver by a range of transporters and is minimally metabolized by cytochrome P450 in healthy volunteers, indicating a reduced potential for drug-drug interactions (DDIs).	pitavastatin	34-46	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	132-147	
24156555-5	2014	EXPERT OPINION: Rosuvastatin and pitavastatin have favorable pharmacokinetic and safety profiles as their disposition does not depend on or is only marginally influenced by cytochrome P450 (CYP) enzymes, thus potentially reducing the risk of drug-drug interactions of these two statins with other drugs known to inhibit CYP enzymes.	pitavastatin	33-45	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	173-188	
24156555-5	2014	EXPERT OPINION: Rosuvastatin and pitavastatin have favorable pharmacokinetic and safety profiles as their disposition does not depend on or is only marginally influenced by cytochrome P450 (CYP) enzymes, thus potentially reducing the risk of drug-drug interactions of these two statins with other drugs known to inhibit CYP enzymes.	pitavastatin	33-45	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	190-193	
24156555-5	2014	EXPERT OPINION: Rosuvastatin and pitavastatin have favorable pharmacokinetic and safety profiles as their disposition does not depend on or is only marginally influenced by cytochrome P450 (CYP) enzymes, thus potentially reducing the risk of drug-drug interactions of these two statins with other drugs known to inhibit CYP enzymes.	pitavastatin	33-45	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	320-323	
22627182-1	2012	OBJECTIVES: Pitavastatin, a statin recently approved in the United States, has a potential benefit of reduced risk of cytochrome P450 (CYP)-mediated drug-drug interaction due to minimal metabolism by the CYP system.	pitavastatin	12-24	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	118-133	
22627182-1	2012	OBJECTIVES: Pitavastatin, a statin recently approved in the United States, has a potential benefit of reduced risk of cytochrome P450 (CYP)-mediated drug-drug interaction due to minimal metabolism by the CYP system.	pitavastatin	12-24	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	135-138	
22627182-1	2012	OBJECTIVES: Pitavastatin, a statin recently approved in the United States, has a potential benefit of reduced risk of cytochrome P450 (CYP)-mediated drug-drug interaction due to minimal metabolism by the CYP system.	pitavastatin	12-24	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	204-207	
15344842-2	2004	Almost the entire radioactivity was from the unchanged substance or lactone form in human hepatocytes, and the cytochrome P450 (CYP)-mediated metabolism of pitavastatin was negligible.	pitavastatin	156-168	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	111-126	
20699675-5	2010	Because pitavastatin is minimally metabolized by the cytochrome P-450 isoenzymes, it is associated with a lower frequency of drug-drug interactions, and this may be a desirable characteristic of pitavastatin.	pitavastatin	8-20	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	53-69	
20699675-5	2010	Because pitavastatin is minimally metabolized by the cytochrome P-450 isoenzymes, it is associated with a lower frequency of drug-drug interactions, and this may be a desirable characteristic of pitavastatin.	pitavastatin	195-207	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	53-69	
15344842-2	2004	Almost the entire radioactivity was from the unchanged substance or lactone form in human hepatocytes, and the cytochrome P450 (CYP)-mediated metabolism of pitavastatin was negligible.	pitavastatin	156-168	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	128-131