PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28404892-7	2017	Gambogic acid also suppressed the EMT induced by TGFbeta1 and tumor necrosis factor alpha by inhibiting the NF-kappaB pathway.	gambogic acid	0-13	tumor necrosis factor	Homo sapiens	62-89	
23640997-1	2013	Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway.	gambogic acid	0-13	tumor necrosis factor	Homo sapiens	68-71	
22472167-3	2012	Herein we report that gambogic acid and its analogs inhibit the activity of IkappaB Kinase-beta (IKKbeta) through suppressing the activation of TNFalpha/NF-kappaB pathway, which in turn induces A549 and U251 cell apoptosis.	gambogic acid	22-35	tumor necrosis factor	Homo sapiens	144-152	
22426696-0	2012	Gambogic acid inhibits TNF-alpha-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-kappaB signaling pathways.	gambogic acid	0-13	tumor necrosis factor	Homo sapiens	23-32	
22426696-1	2012	AIM: To investigate the mechanisms underlying the inhibitory effect of gambogic acid (GA) on TNF-alpha-induced metastasis of human prostate cancer PC3 cells in vitro.	gambogic acid	71-84	tumor necrosis factor	Homo sapiens	93-102	
22426696-1	2012	AIM: To investigate the mechanisms underlying the inhibitory effect of gambogic acid (GA) on TNF-alpha-induced metastasis of human prostate cancer PC3 cells in vitro.	gambogic acid	86-88	tumor necrosis factor	Homo sapiens	93-102	
22426696-7	2012	GA (0.125-0.5 mumol/L) dose-dependently inhibited the migration and invasion of PC3 cells induced by TNF-alpha (10 ng/mL).	gambogic acid	0-2	tumor necrosis factor	Homo sapiens	101-110	
22426696-8	2012	Moreover, the TNF-alpha-mediated activation of phosphatidylinositol-3-OH kinase/protein kinase B (PI3K/Akt) and NF-kappaB pathways was suppressed by GA (0.5 mumol/L).	gambogic acid	149-151	tumor necrosis factor	Homo sapiens	14-23	
22426696-10	2012	Snail expression was significantly down-regulated by treatment with GA (0.5 mumol/L) in the TNF-alpha-stimulated PC3 cells.	gambogic acid	68-70	tumor necrosis factor	Homo sapiens	92-101	
22426696-11	2012	CONCLUSION: GA inhibits TNF-alpha-induced invasion of PC3 cells via inactivation of the PI3K/Akt and NF-kappaB signaling pathways, which may offer a novel approach for the treatment of human prostate cancer.	gambogic acid	12-14	tumor necrosis factor	Homo sapiens	24-33	
21074517-0	2010	Gambogic acid inhibits Hsp90 and deregulates TNF-alpha/NF-kappaB in HeLa cells.	gambogic acid	0-13	tumor necrosis factor	Homo sapiens	45-54	
21074517-2	2010	This study is the first to show that GB inhibits heat shock protein 90 (Hsp90) and down-regulates TNF-alpha/NF-kappaB in HeLa cells.	gambogic acid	37-39	tumor necrosis factor	Homo sapiens	98-107	
21074517-5	2010	Additionally, GB suppresses the activation of TNF-alpha/NF-kappaB and decreases XIAP expression levels and the ratio of Bcl-2/Bax, which in turn induces HeLa cell apoptosis.	gambogic acid	14-16	tumor necrosis factor	Homo sapiens	46-55	
17673602-0	2007	Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway.	gambogic acid	0-13	tumor necrosis factor	Homo sapiens	68-71