PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18226852-10 2008 Collectively, we suggest that GA represses telomerase activity not only by repressing hTERT transcriptional activity via c-Myc but also by posttranslational modification of hTERT via Akt. gambogic acid 30-32 MYC proto-oncogene, bHLH transcription factor Homo sapiens 121-126 23441447-7 2013 Twenty-four hours of treatment with GA (0.5 micromol/L) following transfection with PKM2 siRNA-1 inhibited the vitality of the PC3 cells by 68%, increased their apoptosis, and significantly down-regulated the mRNA and protein levels of c-myc (50% and 35%) and cyclin D1 (60% and 20%) (P < 0.05). gambogic acid 36-38 MYC proto-oncogene, bHLH transcription factor Homo sapiens 236-241 34181351-7 2021 GA attenuated beta-catenin transcriptional levels, decreased beta-catenin protein, and suppressed the expression of c-Myc, a downstream target gene of Wnt/beta-catenin signaling. gambogic acid 0-2 MYC proto-oncogene, bHLH transcription factor Homo sapiens 116-121 16470410-8 2006 The activity of hTERT promoter and the expression of c-MYC were also remarkably decreased in GA-treated cells. gambogic acid 93-95 MYC proto-oncogene, bHLH transcription factor Homo sapiens 53-58 16470410-9 2006 CONCLUSION: This study demonstrated that GA treatment of human gastric carcinoma cell lines, MGC-803 and SGC-7901, significantly reduced the expression of c-MYC in a time- and concentration-dependent manner accompanied with the down-regulation of the hTERT transcription and the ultimate reduction in telomerase activity. gambogic acid 41-43 MYC proto-oncogene, bHLH transcription factor Homo sapiens 155-160 16257012-4 2006 Consistent with the recently reported association between c-MYC overexpression and induction of telomerase activity, we find here that GA treatment of a human hepatoma cell line SMMC-7721 significantly reduced the expression of c-MYC in a time- and concentration-dependent manner accompanied with the down-regulation of the hTERT transcription and the ultimate reduction in telomerase activity. gambogic acid 135-137 MYC proto-oncogene, bHLH transcription factor Homo sapiens 58-63 16257012-4 2006 Consistent with the recently reported association between c-MYC overexpression and induction of telomerase activity, we find here that GA treatment of a human hepatoma cell line SMMC-7721 significantly reduced the expression of c-MYC in a time- and concentration-dependent manner accompanied with the down-regulation of the hTERT transcription and the ultimate reduction in telomerase activity. gambogic acid 135-137 MYC proto-oncogene, bHLH transcription factor Homo sapiens 228-233