PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16257012-4	2006	Consistent with the recently reported association between c-MYC overexpression and induction of telomerase activity, we find here that GA treatment of a human hepatoma cell line SMMC-7721 significantly reduced the expression of c-MYC in a time- and concentration-dependent manner accompanied with the down-regulation of the hTERT transcription and the ultimate reduction in telomerase activity.	gambogic acid	135-137	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	58-63	
16470410-8	2006	The activity of hTERT promoter and the expression of c-MYC were also remarkably decreased in GA-treated cells.	gambogic acid	93-95	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	53-58	
16470410-9	2006	CONCLUSION: This study demonstrated that GA treatment of human gastric carcinoma cell lines, MGC-803 and SGC-7901, significantly reduced the expression of c-MYC in a time- and concentration-dependent manner accompanied with the down-regulation of the hTERT transcription and the ultimate reduction in telomerase activity.	gambogic acid	41-43	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	155-160	
18226852-10	2008	Collectively, we suggest that GA represses telomerase activity not only by repressing hTERT transcriptional activity via c-Myc but also by posttranslational modification of hTERT via Akt.	gambogic acid	30-32	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	121-126	
16257012-4	2006	Consistent with the recently reported association between c-MYC overexpression and induction of telomerase activity, we find here that GA treatment of a human hepatoma cell line SMMC-7721 significantly reduced the expression of c-MYC in a time- and concentration-dependent manner accompanied with the down-regulation of the hTERT transcription and the ultimate reduction in telomerase activity.	gambogic acid	135-137	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	228-233	
34181351-7	2021	GA attenuated beta-catenin transcriptional levels, decreased beta-catenin protein, and suppressed the expression of c-Myc, a downstream target gene of Wnt/beta-catenin signaling.	gambogic acid	0-2	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	116-121	
23441447-7	2013	Twenty-four hours of treatment with GA (0.5 micromol/L) following transfection with PKM2 siRNA-1 inhibited the vitality of the PC3 cells by 68%, increased their apoptosis, and significantly down-regulated the mRNA and protein levels of c-myc (50% and 35%) and cyclin D1 (60% and 20%) (P < 0.05).	gambogic acid	36-38	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	236-241