PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23426995-1 2013 The anticancer activities of gambogic acid (GA) on two hepatocellular carcinoma cells with either p53 deletion (Hep3B) or p53 mutation (Huh7) were investigated in the present study. gambogic acid 29-42 tumor protein p53 Homo sapiens 98-101 28578487-0 2018 Gambogic Acid Induces Cell Apoptosis and Inhibits MAPK Pathway in PTEN-/-/p53-/- Prostate Cancer Cells In Vitro and Ex Vivo. gambogic acid 0-13 tumor protein p53 Homo sapiens 74-77 28578487-16 2018 CONCLUSION: GA was a potent anti-tumor compound as for PTEN-/-/p53-/- PC, which contributed to cell apoptosis via inhibition of the MAPK pathway and c-fos. gambogic acid 12-14 tumor protein p53 Homo sapiens 63-66 29100379-4 2017 We screened eleven traditional Chinese medicines against a panel of androgen-independent Pten/Tp53 null PrCa-derived cell lines and identified gambogic acid (GA) as a highly potent growth inhibitor. gambogic acid 143-156 tumor protein p53 Homo sapiens 94-98 27899303-0 2017 Gambogic acid counteracts mutant p53 stability by inducing autophagy. gambogic acid 0-13 tumor protein p53 Homo sapiens 33-36 27899303-6 2017 We demonstrated that GA may induce mutp53 degradation through autophagy in cancer cells expressing the p53-R280K (MDA-MB-231) and the p53-S241F (DLD1) proteins. gambogic acid 21-23 tumor protein p53 Homo sapiens 38-41 27899303-6 2017 We demonstrated that GA may induce mutp53 degradation through autophagy in cancer cells expressing the p53-R280K (MDA-MB-231) and the p53-S241F (DLD1) proteins. gambogic acid 21-23 tumor protein p53 Homo sapiens 103-106 23426995-1 2013 The anticancer activities of gambogic acid (GA) on two hepatocellular carcinoma cells with either p53 deletion (Hep3B) or p53 mutation (Huh7) were investigated in the present study. gambogic acid 29-42 tumor protein p53 Homo sapiens 122-125 23540934-0 2013 Alpha-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach. gambogic acid 20-33 tumor protein p53 Homo sapiens 65-68 20413215-0 2010 Gambogic acid triggers DNA damage signaling that induces p53/p21(Waf1/CIP1) activation through the ATR-Chk1 pathway. gambogic acid 0-13 tumor protein p53 Homo sapiens 57-60 21268072-0 2011 Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP. gambogic acid 0-13 tumor protein p53 Homo sapiens 44-47 21268072-3 2011 In the present study, we demonstrate that mutant p53 protein stability is regulated by gambogic acid (GA). gambogic acid 87-100 tumor protein p53 Homo sapiens 49-52 21268072-3 2011 In the present study, we demonstrate that mutant p53 protein stability is regulated by gambogic acid (GA). gambogic acid 102-104 tumor protein p53 Homo sapiens 49-52 21268072-4 2011 Following GA exposure, protein levels of mutant p53 decreased while the mRNA levels were not affected in MDA-MB-435 cells, which indicate that GA down-regulates mutant p53 at post-transcription level. gambogic acid 10-12 tumor protein p53 Homo sapiens 48-51 21268072-4 2011 Following GA exposure, protein levels of mutant p53 decreased while the mRNA levels were not affected in MDA-MB-435 cells, which indicate that GA down-regulates mutant p53 at post-transcription level. gambogic acid 10-12 tumor protein p53 Homo sapiens 168-171 21268072-5 2011 Co-treatment with GA and cycloheximide, a protein synthesis inhibitor, induced a decrease of half-life of mutant p53 protein. gambogic acid 18-20 tumor protein p53 Homo sapiens 113-116 21268072-6 2011 These findings indicated that the reduction of mutant p53 by GA was due to the destabilization and degradation of the protein. gambogic acid 61-63 tumor protein p53 Homo sapiens 54-57 21268072-7 2011 Furthermore, inhibition of proteasome activity by MG132 blocked GA-induced down-regulation of mutant p53, causing mutant p53 accumulation in detergent-insoluble cellular fractions. gambogic acid 64-66 tumor protein p53 Homo sapiens 101-104 21268072-7 2011 Furthermore, inhibition of proteasome activity by MG132 blocked GA-induced down-regulation of mutant p53, causing mutant p53 accumulation in detergent-insoluble cellular fractions. gambogic acid 64-66 tumor protein p53 Homo sapiens 121-124 21268072-9 2011 In addition, GA prevented Hsp90/mutant p53 complex formation and enhanced interaction of mutant p53 with Hsp70. gambogic acid 13-15 tumor protein p53 Homo sapiens 39-42 21268072-9 2011 In addition, GA prevented Hsp90/mutant p53 complex formation and enhanced interaction of mutant p53 with Hsp70. gambogic acid 13-15 tumor protein p53 Homo sapiens 96-99 20413215-3 2010 However, GA-induced p53 activation could be partially reversed by caffeine, a PI3k inhibitor. gambogic acid 9-11 tumor protein p53 Homo sapiens 20-23 20413215-4 2010 Therefore, questions of whether GA induces post-translational modifications of p53 and subsequent activation of p53; and if that is the case, which upstream signaling pathway(s) is (are) responsible for that are proposed. gambogic acid 32-34 tumor protein p53 Homo sapiens 79-82 20413215-4 2010 Therefore, questions of whether GA induces post-translational modifications of p53 and subsequent activation of p53; and if that is the case, which upstream signaling pathway(s) is (are) responsible for that are proposed. gambogic acid 32-34 tumor protein p53 Homo sapiens 112-115 20413215-5 2010 Here, the relationship between p53 activation and its post-translational modifications was investigated in the human cancer cell lines HepG2 and A549 in response to GA or adriamycin treatment. gambogic acid 165-167 tumor protein p53 Homo sapiens 31-34 20413215-6 2010 GA induces p53 phosphorylation at sites Ser15 and Ser20 in a concentration- or time-dependent way, which was a direct result of DNA damage, as gamma-HA2X foci and "comet" DNA fragments were detected. gambogic acid 0-2 tumor protein p53 Homo sapiens 11-14 20413215-7 2010 GA induces p53 phosphorylation through activation of an ATM- and Rad3-related pathway, and GA-induced phosphorylation of Chk1 is also involved. gambogic acid 0-2 tumor protein p53 Homo sapiens 11-14 20413215-8 2010 Upon treatment with GA, ATR activation is clearly associated with p53 phosphorylation, as well as activation of its target gene p21(Waf/CIP1). gambogic acid 20-22 tumor protein p53 Homo sapiens 66-69 20071291-5 2009 we found that GA uptake into SPC-A1 cells was higher than into SK-MES-1 cells; apoptosis-related proteins Caspase 2, Caspase 9, Caspase 10, Bax and p53 were involved in GA-induced apoptosis. gambogic acid 14-16 tumor protein p53 Homo sapiens 148-151 19582475-1 2009 PURPOSE: In this study, we investigated the correlation between p53 and bcl-2 in gambogic acid (GA)-induced apoptosis. gambogic acid 81-94 tumor protein p53 Homo sapiens 64-67 19582475-1 2009 PURPOSE: In this study, we investigated the correlation between p53 and bcl-2 in gambogic acid (GA)-induced apoptosis. gambogic acid 96-98 tumor protein p53 Homo sapiens 64-67 19582475-12 2009 CONCLUSIONS: Gambogic acid induced human breast cancer cells MCF-7 apoptosis by reducing bcl-2 expression via p53. gambogic acid 13-26 tumor protein p53 Homo sapiens 110-113 19582475-0 2009 Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells. gambogic acid 0-13 tumor protein p53 Homo sapiens 43-46 20071291-5 2009 we found that GA uptake into SPC-A1 cells was higher than into SK-MES-1 cells; apoptosis-related proteins Caspase 2, Caspase 9, Caspase 10, Bax and p53 were involved in GA-induced apoptosis. gambogic acid 169-171 tumor protein p53 Homo sapiens 148-151 19428175-2 2009 Although it was proved that GA enhances p53 protein level through inhibition of MDM2 in p53 wild-type cancer cells, the mechanisms of MDM2 inhibition especially with the absence of p53 are not fully understood. gambogic acid 28-30 tumor protein p53 Homo sapiens 88-91 19428175-8 2009 Additionally, GA increased p21(Waf1/CIP1) expression in p53 null cancer cells, which was associated with GA-mediated impairing of the interaction between MDM2 and p21(Waf1/CIP1). gambogic acid 14-16 tumor protein p53 Homo sapiens 56-59 19428175-2 2009 Although it was proved that GA enhances p53 protein level through inhibition of MDM2 in p53 wild-type cancer cells, the mechanisms of MDM2 inhibition especially with the absence of p53 are not fully understood. gambogic acid 28-30 tumor protein p53 Homo sapiens 40-43 19428175-2 2009 Although it was proved that GA enhances p53 protein level through inhibition of MDM2 in p53 wild-type cancer cells, the mechanisms of MDM2 inhibition especially with the absence of p53 are not fully understood. gambogic acid 28-30 tumor protein p53 Homo sapiens 88-91 19428175-9 2009 Furthermore, the apoptosis, cytotoxicity and G2/M cell cycle arrest induced by GA were detected in both p53 wild-type and p53 null cancer cells. gambogic acid 79-81 tumor protein p53 Homo sapiens 104-107 19428175-9 2009 Furthermore, the apoptosis, cytotoxicity and G2/M cell cycle arrest induced by GA were detected in both p53 wild-type and p53 null cancer cells. gambogic acid 79-81 tumor protein p53 Homo sapiens 122-125 19428175-11 2009 It is concluded that GA down-regulates the MDM2 oncogene and exerts the anti-tumor activity independent of p53, and therefore provide more evidences for its therapeutic application. gambogic acid 21-23 tumor protein p53 Homo sapiens 107-110 34149899-6 2021 Compared with the PBS control group, the A549, A549/DDP and A549/Taxol cells treated with NaI131, GA or a combination of the drugs exhibited G2/M arrest and increased percentages of total apoptotic cells, as well as significantly decreased protein levels of CDK1, cyclin B, mtp53, HSP90, Bcl-2 and P-gp, increased protein levels of Bax and decreased mRNA levels of p53 and HSP90. gambogic acid 98-100 tumor protein p53 Homo sapiens 365-368