PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28797284-10	2017	In particular, gambogic acid reduced the expression of the ribonucleotide reductase subunit-M2 (RRM2) protein and mRNA, a trend that correlated with resistance to gemcitabine through inhibition of the extracellular signal-regulated kinase (ERK)/E2F1 signaling pathway.	gambogic acid	15-28	mitogen-activated protein kinase 1	Homo sapiens	201-238	
28797284-10	2017	In particular, gambogic acid reduced the expression of the ribonucleotide reductase subunit-M2 (RRM2) protein and mRNA, a trend that correlated with resistance to gemcitabine through inhibition of the extracellular signal-regulated kinase (ERK)/E2F1 signaling pathway.	gambogic acid	15-28	mitogen-activated protein kinase 1	Homo sapiens	240-243	
28797284-13	2017	CONCLUSIONS: These results demonstrate that gambogic acid sensitizes pancreatic cancer cells to gemcitabine in vitro and in vivo by inhibiting the activation of the ERK/E2F1/RRM2 signaling pathway.	gambogic acid	44-57	mitogen-activated protein kinase 1	Homo sapiens	165-168	
25887496-12	2015	CONCLUSIONS: These results suggest that GA induce apoptosis associated with the ER stress response through up-regulation of p-JNK and down-regulation of p-ERK in HeLa cells.	gambogic acid	40-42	mitogen-activated protein kinase 1	Homo sapiens	155-158