PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34331200-3 2021 The bioactive natural compound gambogic acid (GB) is a prenylated xanthone with antitumor activity, and it has been proposed to function as an HSP90 inhibitor. gambogic acid 31-44 heat shock protein 90 alpha family class A member 1 Homo sapiens 143-148 34494397-5 2021 Gambogic acid (GA) which surmounts tumor cell thermotolerance by inhibiting heat shock protein 90 (HSP90) expression is coloaded into the nanoparticles, RGD peptide is further introduced to the nanoparticle surface to improve tumor accumulation. gambogic acid 0-13 heat shock protein 90 alpha family class A member 1 Homo sapiens 76-97 34494397-5 2021 Gambogic acid (GA) which surmounts tumor cell thermotolerance by inhibiting heat shock protein 90 (HSP90) expression is coloaded into the nanoparticles, RGD peptide is further introduced to the nanoparticle surface to improve tumor accumulation. gambogic acid 0-13 heat shock protein 90 alpha family class A member 1 Homo sapiens 99-104 34331200-0 2021 Gambogic acid and gambogenic acid induce a thiol-dependent heat shock response and disrupt the interaction between HSP90 and HSF1 or HSF2. gambogic acid 0-13 heat shock protein 90 alpha family class A member 1 Homo sapiens 115-120 34778741-5 2021 Meanwhile, GA could inhibit heat shock protein 90 (HSP90) to reduce the heat resistance of tumor cells, and forcefully consume glutathione (GSH) to weaken the antioxidant capacity of cells. gambogic acid 11-13 heat shock protein 90 alpha family class A member 1 Homo sapiens 28-49 34778741-5 2021 Meanwhile, GA could inhibit heat shock protein 90 (HSP90) to reduce the heat resistance of tumor cells, and forcefully consume glutathione (GSH) to weaken the antioxidant capacity of cells. gambogic acid 11-13 heat shock protein 90 alpha family class A member 1 Homo sapiens 51-56 34331200-3 2021 The bioactive natural compound gambogic acid (GB) is a prenylated xanthone with antitumor activity, and it has been proposed to function as an HSP90 inhibitor. gambogic acid 46-48 heat shock protein 90 alpha family class A member 1 Homo sapiens 143-148 34331200-8 2021 GB and GBA treatment disrupt the interaction between HSP90 and HSF1 and HSP90 and HSF2. gambogic acid 0-2 heat shock protein 90 alpha family class A member 1 Homo sapiens 53-58 34331200-8 2021 GB and GBA treatment disrupt the interaction between HSP90 and HSF1 and HSP90 and HSF2. gambogic acid 0-2 heat shock protein 90 alpha family class A member 1 Homo sapiens 72-77 34331200-9 2021 Our study implies that these compounds should be used cautiously if developed for cancer therapies, since GB and its derivative GBA are strong inducers of the HSR, in multiple cell types, by involving the dissociation of a HSP90-HSF1/HSF2 complex. gambogic acid 106-108 heat shock protein 90 alpha family class A member 1 Homo sapiens 223-228 32785323-5 2020 Then, gambogic acid, a natural inhibitor of Hsp90, was efficiently loaded onto the BZ nanomaterial via physical mixing. gambogic acid 6-19 heat shock protein 90 alpha family class A member 1 Homo sapiens 44-49 34149899-6 2021 Compared with the PBS control group, the A549, A549/DDP and A549/Taxol cells treated with NaI131, GA or a combination of the drugs exhibited G2/M arrest and increased percentages of total apoptotic cells, as well as significantly decreased protein levels of CDK1, cyclin B, mtp53, HSP90, Bcl-2 and P-gp, increased protein levels of Bax and decreased mRNA levels of p53 and HSP90. gambogic acid 98-100 heat shock protein 90 alpha family class A member 1 Homo sapiens 281-286 34149899-6 2021 Compared with the PBS control group, the A549, A549/DDP and A549/Taxol cells treated with NaI131, GA or a combination of the drugs exhibited G2/M arrest and increased percentages of total apoptotic cells, as well as significantly decreased protein levels of CDK1, cyclin B, mtp53, HSP90, Bcl-2 and P-gp, increased protein levels of Bax and decreased mRNA levels of p53 and HSP90. gambogic acid 98-100 heat shock protein 90 alpha family class A member 1 Homo sapiens 373-378 34878465-5 2022 The released GA could enhance the NIR-II PTT efficacy by inhibiting the activity of HSP90, reducing the thermoresistance of tumors, exhibiting significant chemotherapeutic effects, and achieving synergistic anti-tumor efficiency. gambogic acid 13-15 heat shock protein 90 alpha family class A member 1 Homo sapiens 84-89 33407570-4 2021 RESULTS: Near-infrared photosensitizer (IR780) and gambogic acid (GA, Hsp90 inhibitor) were encapsulated into albumin nanoparticles via hydrophobic interaction, which was further deposited MnO2 on the surface to form IGM nanoparticles. gambogic acid 51-64 heat shock protein 90 alpha family class A member 1 Homo sapiens 70-75 33407570-7 2021 In addition, the release of GA was promoted by irradiation to bind with Hsp90, which could reduce cell tolerance to heat for PTT enhancement. gambogic acid 28-30 heat shock protein 90 alpha family class A member 1 Homo sapiens 72-77 27466407-4 2016 We show that the natural product, gambogic acid (GBA), binds selectively to a site in the middle domain of Hsp90beta, identifying GBA as an Hsp90beta-specific Hsp90 inhibitor. gambogic acid 34-47 heat shock protein 90 alpha family class A member 1 Homo sapiens 107-112 32627780-6 2020 Interestingly, combined with hydrophobic gambogic acid (GA) which can downregulate heat shock protein 90 (HSP90), the HMCS-PEG-GA system showed a significant NIR-enhanced tumor therapeutic effect in vitro and in vivo under mild temperature conditions (~43 C), and the combination index (CI) value of HMCS-PEG-GA was found to be 0.72. gambogic acid 41-54 heat shock protein 90 alpha family class A member 1 Homo sapiens 83-104 32627780-6 2020 Interestingly, combined with hydrophobic gambogic acid (GA) which can downregulate heat shock protein 90 (HSP90), the HMCS-PEG-GA system showed a significant NIR-enhanced tumor therapeutic effect in vitro and in vivo under mild temperature conditions (~43 C), and the combination index (CI) value of HMCS-PEG-GA was found to be 0.72. gambogic acid 41-54 heat shock protein 90 alpha family class A member 1 Homo sapiens 106-111 32627780-6 2020 Interestingly, combined with hydrophobic gambogic acid (GA) which can downregulate heat shock protein 90 (HSP90), the HMCS-PEG-GA system showed a significant NIR-enhanced tumor therapeutic effect in vitro and in vivo under mild temperature conditions (~43 C), and the combination index (CI) value of HMCS-PEG-GA was found to be 0.72. gambogic acid 56-58 heat shock protein 90 alpha family class A member 1 Homo sapiens 83-104 32627780-6 2020 Interestingly, combined with hydrophobic gambogic acid (GA) which can downregulate heat shock protein 90 (HSP90), the HMCS-PEG-GA system showed a significant NIR-enhanced tumor therapeutic effect in vitro and in vivo under mild temperature conditions (~43 C), and the combination index (CI) value of HMCS-PEG-GA was found to be 0.72. gambogic acid 56-58 heat shock protein 90 alpha family class A member 1 Homo sapiens 106-111 32627780-6 2020 Interestingly, combined with hydrophobic gambogic acid (GA) which can downregulate heat shock protein 90 (HSP90), the HMCS-PEG-GA system showed a significant NIR-enhanced tumor therapeutic effect in vitro and in vivo under mild temperature conditions (~43 C), and the combination index (CI) value of HMCS-PEG-GA was found to be 0.72. gambogic acid 127-129 heat shock protein 90 alpha family class A member 1 Homo sapiens 83-104 32627780-6 2020 Interestingly, combined with hydrophobic gambogic acid (GA) which can downregulate heat shock protein 90 (HSP90), the HMCS-PEG-GA system showed a significant NIR-enhanced tumor therapeutic effect in vitro and in vivo under mild temperature conditions (~43 C), and the combination index (CI) value of HMCS-PEG-GA was found to be 0.72. gambogic acid 127-129 heat shock protein 90 alpha family class A member 1 Homo sapiens 106-111 32627780-6 2020 Interestingly, combined with hydrophobic gambogic acid (GA) which can downregulate heat shock protein 90 (HSP90), the HMCS-PEG-GA system showed a significant NIR-enhanced tumor therapeutic effect in vitro and in vivo under mild temperature conditions (~43 C), and the combination index (CI) value of HMCS-PEG-GA was found to be 0.72. gambogic acid 126-129 heat shock protein 90 alpha family class A member 1 Homo sapiens 83-104 32627780-6 2020 Interestingly, combined with hydrophobic gambogic acid (GA) which can downregulate heat shock protein 90 (HSP90), the HMCS-PEG-GA system showed a significant NIR-enhanced tumor therapeutic effect in vitro and in vivo under mild temperature conditions (~43 C), and the combination index (CI) value of HMCS-PEG-GA was found to be 0.72. gambogic acid 126-129 heat shock protein 90 alpha family class A member 1 Homo sapiens 106-111 29664615-0 2018 The Noncompetitive Effect of Gambogic Acid Displaces Fluorescence-Labeled ATP but Requires ATP for Binding to Hsp90/HtpG. gambogic acid 29-42 heat shock protein 90 alpha family class A member 1 Homo sapiens 110-115 29664615-3 2018 It was shown that gambogic acid (GBA) has the potential to inhibit human Hsp90. gambogic acid 18-31 heat shock protein 90 alpha family class A member 1 Homo sapiens 73-78 27527413-2 2016 Gambogic acid (GA), the main active compound of Gamboge hanburyi, has been reported as a natural inhibitor of Hsp90. gambogic acid 0-13 heat shock protein 90 alpha family class A member 1 Homo sapiens 110-115 27527413-2 2016 Gambogic acid (GA), the main active compound of Gamboge hanburyi, has been reported as a natural inhibitor of Hsp90. gambogic acid 15-17 heat shock protein 90 alpha family class A member 1 Homo sapiens 110-115 21486005-0 2011 Gambogic acid, a natural product inhibitor of Hsp90. gambogic acid 0-13 heat shock protein 90 alpha family class A member 1 Homo sapiens 46-51 21486005-1 2011 A high-throughput screening of natural product libraries identified (-)-gambogic acid (1), a component of the exudate of Garcinia harburyi, as a potential Hsp90 inhibitor, in addition to the known Hsp90 inhibitor celastrol (2). gambogic acid 68-85 heat shock protein 90 alpha family class A member 1 Homo sapiens 155-160 21486005-3 2011 Gambogic acid also disrupted the interaction of Hsp90, Hsp70, and Cdc37 with the heme-regulated eIF2alpha kinase (HRI, an Hsp90-dependent client) and blocked the maturation of HRI in vitro. gambogic acid 0-13 heat shock protein 90 alpha family class A member 1 Homo sapiens 48-53 21486005-3 2011 Gambogic acid also disrupted the interaction of Hsp90, Hsp70, and Cdc37 with the heme-regulated eIF2alpha kinase (HRI, an Hsp90-dependent client) and blocked the maturation of HRI in vitro. gambogic acid 0-13 heat shock protein 90 alpha family class A member 1 Homo sapiens 122-127 21268072-9 2011 In addition, GA prevented Hsp90/mutant p53 complex formation and enhanced interaction of mutant p53 with Hsp70. gambogic acid 13-15 heat shock protein 90 alpha family class A member 1 Homo sapiens 26-31 21074517-0 2010 Gambogic acid inhibits Hsp90 and deregulates TNF-alpha/NF-kappaB in HeLa cells. gambogic acid 0-13 heat shock protein 90 alpha family class A member 1 Homo sapiens 23-28 21074517-2 2010 This study is the first to show that GB inhibits heat shock protein 90 (Hsp90) and down-regulates TNF-alpha/NF-kappaB in HeLa cells. gambogic acid 37-39 heat shock protein 90 alpha family class A member 1 Homo sapiens 49-70 21074517-2 2010 This study is the first to show that GB inhibits heat shock protein 90 (Hsp90) and down-regulates TNF-alpha/NF-kappaB in HeLa cells. gambogic acid 37-39 heat shock protein 90 alpha family class A member 1 Homo sapiens 72-77 21074517-3 2010 The effects of GB on Hsp90 were studied by characterizing its physical interactions with Hsp90 upon binding, the noncompetitive inhibition of Hsp90 ATPase activity, and the degradation of Hsp90 client proteins (i.e., Akt, IKK) in HeLa cells. gambogic acid 15-17 heat shock protein 90 alpha family class A member 1 Homo sapiens 21-26 21074517-3 2010 The effects of GB on Hsp90 were studied by characterizing its physical interactions with Hsp90 upon binding, the noncompetitive inhibition of Hsp90 ATPase activity, and the degradation of Hsp90 client proteins (i.e., Akt, IKK) in HeLa cells. gambogic acid 15-17 heat shock protein 90 alpha family class A member 1 Homo sapiens 89-94 21074517-3 2010 The effects of GB on Hsp90 were studied by characterizing its physical interactions with Hsp90 upon binding, the noncompetitive inhibition of Hsp90 ATPase activity, and the degradation of Hsp90 client proteins (i.e., Akt, IKK) in HeLa cells. gambogic acid 15-17 heat shock protein 90 alpha family class A member 1 Homo sapiens 89-94 21074517-3 2010 The effects of GB on Hsp90 were studied by characterizing its physical interactions with Hsp90 upon binding, the noncompetitive inhibition of Hsp90 ATPase activity, and the degradation of Hsp90 client proteins (i.e., Akt, IKK) in HeLa cells. gambogic acid 15-17 heat shock protein 90 alpha family class A member 1 Homo sapiens 89-94 21074517-4 2010 GB seems to bind to the N-terminal ATP-binding domain of Hsp90. gambogic acid 0-2 heat shock protein 90 alpha family class A member 1 Homo sapiens 57-62 21074517-6 2010 Thus, GB represents a promising therapeutic agent for cancer; it may also be useful as a probe to increase understanding of the biological functions of Hsp90. gambogic acid 6-8 heat shock protein 90 alpha family class A member 1 Homo sapiens 152-157