PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18298900-8 2008 Treated by GA, the expression of DIO-1 was upregulated, and that of Bcl-2 and NF-kappaB was downregulated, leading to the activation of pro-caspase 3. gambogic acid 11-13 nuclear factor kappa B subunit 1 Homo sapiens 78-87 24300974-0 2014 Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-kappaB and MAPK/HO-1 signalling. gambogic acid 0-13 nuclear factor kappa B subunit 1 Homo sapiens 120-129 28404892-6 2017 Gambogic acid inhibited NF-kappaB p65 nuclear translocation and the phosphorylation of the inhibitor of NF-kappaB (IkappaBalpha) and IkappaBalpha kinase (IKKalpha). gambogic acid 0-13 nuclear factor kappa B subunit 1 Homo sapiens 24-33 28404892-6 2017 Gambogic acid inhibited NF-kappaB p65 nuclear translocation and the phosphorylation of the inhibitor of NF-kappaB (IkappaBalpha) and IkappaBalpha kinase (IKKalpha). gambogic acid 0-13 nuclear factor kappa B subunit 1 Homo sapiens 104-113 28404892-7 2017 Gambogic acid also suppressed the EMT induced by TGFbeta1 and tumor necrosis factor alpha by inhibiting the NF-kappaB pathway. gambogic acid 0-13 nuclear factor kappa B subunit 1 Homo sapiens 108-117 27284372-0 2016 Apoptotic effect of gambogic acid in esophageal squamous cell carcinoma cells via suppression of the NF-kappaB pathway. gambogic acid 20-33 nuclear factor kappa B subunit 1 Homo sapiens 101-110 27284372-6 2016 The inhibition of protein kinase B (AKT) and NF-kappaB activation by chemical inhibitors augmented the apoptotic effect responses to GA in the TE-1 cells. gambogic acid 133-135 nuclear factor kappa B subunit 1 Homo sapiens 45-54 27284372-9 2016 GA induced apoptosis in ESCC TE-1 via suppression of NF-kappaB pathway. gambogic acid 0-2 nuclear factor kappa B subunit 1 Homo sapiens 53-62 24245692-0 2014 Suppression of NF-kappaB signaling and P-glycoprotein function by gambogic acid synergistically potentiates adriamycin -induced apoptosis in lung cancer. gambogic acid 66-79 nuclear factor kappa B subunit 1 Homo sapiens 15-24 24245692-9 2014 The critical role of NF-kappaB was further confirmed by using PDTC, a NF-kappaB inhibitor, which significantly increased apoptosis induction by the combination of GA and ADM and inhibited ADM-induced ABCB1 upregulation. gambogic acid 163-165 nuclear factor kappa B subunit 1 Homo sapiens 21-30 24245692-9 2014 The critical role of NF-kappaB was further confirmed by using PDTC, a NF-kappaB inhibitor, which significantly increased apoptosis induction by the combination of GA and ADM and inhibited ADM-induced ABCB1 upregulation. gambogic acid 163-165 nuclear factor kappa B subunit 1 Homo sapiens 70-79 24245692-10 2014 Importantly, our results indicated that the combination of GA and ADM exerted enhanced anti-tumor effects on A549 xenograft models through inhibiting NF-kappaB and P-glycoprotein, and attenuated ADM-induced cardiotoxicity. gambogic acid 59-61 nuclear factor kappa B subunit 1 Homo sapiens 150-159 25218692-0 2014 Gambogic acid induced oxidative stress dependent caspase activation regulates both apoptosis and autophagy by targeting various key molecules (NF-kappaB, Beclin-1, p62 and NBR1) in human bladder cancer cells. gambogic acid 0-13 nuclear factor kappa B subunit 1 Homo sapiens 143-152 25218692-8 2014 Gambogic acid abrogates NF-kappaB activation by ROS mediated inhibition of IkappaB-alpha phosphorylation. gambogic acid 0-13 nuclear factor kappa B subunit 1 Homo sapiens 24-33 24300974-9 2014 The roles of NF-kappaB and MAPK pathways were further confirmed by using specific inhibitors, which significantly increased ROS release and apoptosis induced by the sequential combination of CDDP and GA. gambogic acid 200-202 nuclear factor kappa B subunit 1 Homo sapiens 13-22 24300974-8 2014 Importantly, it was found that, followed by CDDP treatment, GA could inhibit NF-kappaB and mitogen-activated protein kinase (MAPK)/heme oxygenase-1 (HO-1) signalling pathways, which have been validated to reduce ROS release and confer CDDP resistance. gambogic acid 60-62 nuclear factor kappa B subunit 1 Homo sapiens 77-86 24300974-10 2014 Moreover, our results indicated that the combination of CDDP and GA exerted increased antitumour effects on A549 xenograft models through inhibiting NF-kappaB, HO-1, and subsequently inducing apoptosis. gambogic acid 65-67 nuclear factor kappa B subunit 1 Homo sapiens 149-158 24300974-11 2014 CONCLUSION: Gambogic acid sensitises lung cancer cells to CDDP in vitro and in vivo in NSCLC through inactivation of NF-kappaB and MAPK/HO-1 signalling pathways, providing a rationale for the combined use of CDDP and GA in lung cancer chemotherapy. gambogic acid 12-25 nuclear factor kappa B subunit 1 Homo sapiens 117-126 21074517-0 2010 Gambogic acid inhibits Hsp90 and deregulates TNF-alpha/NF-kappaB in HeLa cells. gambogic acid 0-13 nuclear factor kappa B subunit 1 Homo sapiens 55-64 22472167-3 2012 Herein we report that gambogic acid and its analogs inhibit the activity of IkappaB Kinase-beta (IKKbeta) through suppressing the activation of TNFalpha/NF-kappaB pathway, which in turn induces A549 and U251 cell apoptosis. gambogic acid 22-35 nuclear factor kappa B subunit 1 Homo sapiens 153-162 23991348-0 2013 Gambogic acid moderates cardiac responses to chronic hypoxia likely by acting on the proteasome and NF-kappaB pathway. gambogic acid 0-13 nuclear factor kappa B subunit 1 Homo sapiens 100-109 23991348-7 2013 The results showed that GA could accumulate the IkappaB levels associated with decreased proteasomal activity, block the translocation of NF-kappaB from the cytoplasm to the nucleus, decrease NF-kappaB DNA-binding activity, and reduce IL-2 levels. gambogic acid 24-26 nuclear factor kappa B subunit 1 Homo sapiens 138-147 23991348-7 2013 The results showed that GA could accumulate the IkappaB levels associated with decreased proteasomal activity, block the translocation of NF-kappaB from the cytoplasm to the nucleus, decrease NF-kappaB DNA-binding activity, and reduce IL-2 levels. gambogic acid 24-26 nuclear factor kappa B subunit 1 Homo sapiens 192-201 21074517-2 2010 This study is the first to show that GB inhibits heat shock protein 90 (Hsp90) and down-regulates TNF-alpha/NF-kappaB in HeLa cells. gambogic acid 37-39 nuclear factor kappa B subunit 1 Homo sapiens 108-117 21074517-5 2010 Additionally, GB suppresses the activation of TNF-alpha/NF-kappaB and decreases XIAP expression levels and the ratio of Bcl-2/Bax, which in turn induces HeLa cell apoptosis. gambogic acid 14-16 nuclear factor kappa B subunit 1 Homo sapiens 56-65 19778460-0 2009 The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma. gambogic acid 77-90 nuclear factor kappa B subunit 1 Homo sapiens 4-14 19778460-9 2009 RESULTS: The results showed that GA could inhibit the proliferation and induce the apoptosis of the oral squamous cell carcinoma cell lines and that the NF-kappa B pathway was simultaneously activated by GA treatment. gambogic acid 204-206 nuclear factor kappa B subunit 1 Homo sapiens 153-163 19778460-10 2009 The minimal cytotoxic dose of celastrol was able to effectively suppress the GA-induced NF-kappa B pathway activation. gambogic acid 77-79 nuclear factor kappa B subunit 1 Homo sapiens 88-98