PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24334603-0 2014 Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation. gambogic acid 0-13 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 142-149 24334603-8 2014 RESULTS: Gambogic acid induced apoptosis and cell proliferation inhibition in CML cells and inhibited the growth of imatinib-resistant Bcr-Abl-T315I xenografts in nude mice. gambogic acid 9-22 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 135-142 24334603-10 2014 CONCLUSIONS: These findings suggest an alternative strategy to overcome imatinib resistance by enhancing Bcr-Abl downregulation with the medicinal compound gambogic acid, which may have great clinical significance in imatinib-resistant cancer therapy. gambogic acid 156-169 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 105-112