PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24835506-0 2014 Gambogic acid induces growth inhibition and differentiation via upregulation of p21waf1/cip1 expression in acute myeloid leukemia cells. gambogic acid 0-13 cyclin dependent kinase inhibitor 1A Homo sapiens 88-92 24835506-5 2014 In addition, GA upregulated the expression of p21waf1/cip1 in the two cell lines. gambogic acid 13-15 cyclin dependent kinase inhibitor 1A Homo sapiens 46-58 24835506-6 2014 Finally, downregulating the p21waf1/cip1 expression with small interfering RNA partially blocked GA-induced cell growth inhibition and differentiation. gambogic acid 97-99 cyclin dependent kinase inhibitor 1A Homo sapiens 36-40 20413215-0 2010 Gambogic acid triggers DNA damage signaling that induces p53/p21(Waf1/CIP1) activation through the ATR-Chk1 pathway. gambogic acid 0-13 cyclin dependent kinase inhibitor 1A Homo sapiens 61-74 20413215-8 2010 Upon treatment with GA, ATR activation is clearly associated with p53 phosphorylation, as well as activation of its target gene p21(Waf/CIP1). gambogic acid 20-22 cyclin dependent kinase inhibitor 1A Homo sapiens 128-131 20413215-8 2010 Upon treatment with GA, ATR activation is clearly associated with p53 phosphorylation, as well as activation of its target gene p21(Waf/CIP1). gambogic acid 20-22 cyclin dependent kinase inhibitor 1A Homo sapiens 136-140 19428175-8 2009 Additionally, GA increased p21(Waf1/CIP1) expression in p53 null cancer cells, which was associated with GA-mediated impairing of the interaction between MDM2 and p21(Waf1/CIP1). gambogic acid 14-16 cyclin dependent kinase inhibitor 1A Homo sapiens 27-30 19428175-0 2009 Gambogic acid down-regulates MDM2 oncogene and induces p21(Waf1/CIP1) expression independent of p53. gambogic acid 0-13 cyclin dependent kinase inhibitor 1A Homo sapiens 55-58 19428175-0 2009 Gambogic acid down-regulates MDM2 oncogene and induces p21(Waf1/CIP1) expression independent of p53. gambogic acid 0-13 cyclin dependent kinase inhibitor 1A Homo sapiens 59-63 19428175-0 2009 Gambogic acid down-regulates MDM2 oncogene and induces p21(Waf1/CIP1) expression independent of p53. gambogic acid 0-13 cyclin dependent kinase inhibitor 1A Homo sapiens 64-68 19428175-8 2009 Additionally, GA increased p21(Waf1/CIP1) expression in p53 null cancer cells, which was associated with GA-mediated impairing of the interaction between MDM2 and p21(Waf1/CIP1). gambogic acid 14-16 cyclin dependent kinase inhibitor 1A Homo sapiens 31-35 19428175-8 2009 Additionally, GA increased p21(Waf1/CIP1) expression in p53 null cancer cells, which was associated with GA-mediated impairing of the interaction between MDM2 and p21(Waf1/CIP1). gambogic acid 14-16 cyclin dependent kinase inhibitor 1A Homo sapiens 36-40 19428175-8 2009 Additionally, GA increased p21(Waf1/CIP1) expression in p53 null cancer cells, which was associated with GA-mediated impairing of the interaction between MDM2 and p21(Waf1/CIP1). gambogic acid 14-16 cyclin dependent kinase inhibitor 1A Homo sapiens 163-166 19428175-8 2009 Additionally, GA increased p21(Waf1/CIP1) expression in p53 null cancer cells, which was associated with GA-mediated impairing of the interaction between MDM2 and p21(Waf1/CIP1). gambogic acid 14-16 cyclin dependent kinase inhibitor 1A Homo sapiens 167-171 19428175-8 2009 Additionally, GA increased p21(Waf1/CIP1) expression in p53 null cancer cells, which was associated with GA-mediated impairing of the interaction between MDM2 and p21(Waf1/CIP1). gambogic acid 14-16 cyclin dependent kinase inhibitor 1A Homo sapiens 172-176