PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19236754-5 2009 The results showed that the Gambogic acid dose-dependently induced the apoptosis of Raji cells, downregulated the expression of Bcl-xL, upregulated the expressions of DIO-1 and pro-caspase 3, induced the cleavage of pro-caspase 3 and DIO nuclear translocation. gambogic acid 28-41 BCL2 like 1 Homo sapiens 128-134 19236754-6 2009 It is concluded that gambogic acid induces the apoptosis of Raji cells through DIO-1 upregulation, nuclear translocation, Bcl-xL downregulation and caspase 3 activation. gambogic acid 21-34 BCL2 like 1 Homo sapiens 122-128 19067680-2 2008 We demonstrate here that gambogic acid also present powerful antileukaemic potency through both growth arrest and apoptosis induction in Jurkat cells, which was accompanied by typical apoptotic morphological changes and sharp decreased expression of Bcl-xL and Bcl-2. gambogic acid 25-38 BCL2 like 1 Homo sapiens 250-256 23404459-5 2013 However, lower concentration GA significantly downregulated the expression of anti-apoptotic protein including Bcl-2, Bcl-xL, and Mcl-1, which also dramatically activated cleaved caspase-9 and -3 in a dose- and time-dependent manner. gambogic acid 29-31 BCL2 like 1 Homo sapiens 118-124