PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23426995-5 2013 GA induced apoptosis in the two cell lines through caspases-3/7, -8 and -9 in the mitochondrial pathway. gambogic acid 0-2 caspase 3 Homo sapiens 51-74 24490857-8 2014 MJ enhanced GA-induced activation of caspase-3 and caspase-9, and down-regulated the expression of XIAP. gambogic acid 12-14 caspase 3 Homo sapiens 37-46 22739161-6 2012 The positive cell number of activated caspase 3, caspase 8, caspase 9 and the levels of activated caspase 3, caspase 9, p-JNK, P38 increased after Jurkat cells were treated with GA. ROS, CaMKII, caspase 3, caspase 9, MAPKK, JNK1/2 and P38 inhibitors had some significant effect on GA-induced apoptosis. gambogic acid 178-180 caspase 3 Homo sapiens 38-47 23194187-5 2012 Furthermore, GA induced PARP cleavage, activation of caspase-3, caspase-8, and caspase-9, as well as an increased ratio of Bax/Bcl-2. gambogic acid 13-15 caspase 3 Homo sapiens 53-62 23592899-7 2013 GA induces apoptosis in JeKo-1 cells but not in normal bone marrow cells, which was involved in reducing the membrane potential of mitochondria, activating caspases-3, -8 and -9 and decreasing the ratio of Bcl-2 and Bax without cell cycle arresting. gambogic acid 0-2 caspase 3 Homo sapiens 156-177 23592899-8 2013 CONCLUSIONS: GA induced apoptosis in human MCL JeKo-1 cells by regulating Bcl-2/Bax and activating caspase-3, -8 and -9 via mitochondrial pathway without affecting cell cycle. gambogic acid 13-15 caspase 3 Homo sapiens 99-119 22739161-6 2012 The positive cell number of activated caspase 3, caspase 8, caspase 9 and the levels of activated caspase 3, caspase 9, p-JNK, P38 increased after Jurkat cells were treated with GA. ROS, CaMKII, caspase 3, caspase 9, MAPKK, JNK1/2 and P38 inhibitors had some significant effect on GA-induced apoptosis. gambogic acid 178-180 caspase 3 Homo sapiens 98-107 22739161-6 2012 The positive cell number of activated caspase 3, caspase 8, caspase 9 and the levels of activated caspase 3, caspase 9, p-JNK, P38 increased after Jurkat cells were treated with GA. ROS, CaMKII, caspase 3, caspase 9, MAPKK, JNK1/2 and P38 inhibitors had some significant effect on GA-induced apoptosis. gambogic acid 178-180 caspase 3 Homo sapiens 98-107 22783411-0 2012 Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS. gambogic acid 11-24 caspase 3 Homo sapiens 46-55 22783411-12 2012 In conclusion, our study found that GA is able to induce apoptosis in RPMI-8226 cells via ROS accumulation followed by caspase-3 activation, PARP cleavage and SIRT1 downregulation. gambogic acid 36-38 caspase 3 Homo sapiens 119-128 34181351-6 2021 RESULTS: GA exhibited potent cytotoxicity in CCA cells which was associated with significantly inhibited cell proliferation, promoted G1 arrest, and activated caspase 3 mediated-apoptosis. gambogic acid 9-11 caspase 3 Homo sapiens 159-168 22888247-7 2012 Transcription of cytochrome c, caspase 9, and caspase 3 genes was higher in the group treated with magnetic nanoparticles containing Fe(3)O(4) and gambogic acid than in the groups that received gambogic acid or magnetic nanoparticles containing Fe(3)O(4), but transcription of phosphatidylinositol 3-kinase, Akt, and Bad genes decreased. gambogic acid 147-160 caspase 3 Homo sapiens 46-55 22888247-7 2012 Transcription of cytochrome c, caspase 9, and caspase 3 genes was higher in the group treated with magnetic nanoparticles containing Fe(3)O(4) and gambogic acid than in the groups that received gambogic acid or magnetic nanoparticles containing Fe(3)O(4), but transcription of phosphatidylinositol 3-kinase, Akt, and Bad genes decreased. gambogic acid 194-207 caspase 3 Homo sapiens 46-55 22888247-8 2012 Notably, expression of cytochrome c, caspase 9, and caspase 3 proteins in the group treated with gambogic acid and magnetic nanoparticles containing Fe(3)O(4) was higher than in the groups receiving magnetic nanoparticles containing Fe(3)O(4) or gambogic acid, while expression of p-PI3K, p-Akt, p-Bad, pro-caspase 9, and pro-caspase 3 degraded. gambogic acid 97-110 caspase 3 Homo sapiens 52-61 22888247-8 2012 Notably, expression of cytochrome c, caspase 9, and caspase 3 proteins in the group treated with gambogic acid and magnetic nanoparticles containing Fe(3)O(4) was higher than in the groups receiving magnetic nanoparticles containing Fe(3)O(4) or gambogic acid, while expression of p-PI3K, p-Akt, p-Bad, pro-caspase 9, and pro-caspase 3 degraded. gambogic acid 97-110 caspase 3 Homo sapiens 322-335 20030923-10 2009 GA could decrease the mitochondrial membrane potential and increase the activated caspase 3, caspase 8, caspase 9 positive cell levels by 2.19%, -1.95%, 34.01% in 24 hr and 60.4%, 71.3%, 77.7% in 48 hr respectively. gambogic acid 0-2 caspase 3 Homo sapiens 82-91 19236754-5 2009 The results showed that the Gambogic acid dose-dependently induced the apoptosis of Raji cells, downregulated the expression of Bcl-xL, upregulated the expressions of DIO-1 and pro-caspase 3, induced the cleavage of pro-caspase 3 and DIO nuclear translocation. gambogic acid 28-41 caspase 3 Homo sapiens 177-190 19236754-5 2009 The results showed that the Gambogic acid dose-dependently induced the apoptosis of Raji cells, downregulated the expression of Bcl-xL, upregulated the expressions of DIO-1 and pro-caspase 3, induced the cleavage of pro-caspase 3 and DIO nuclear translocation. gambogic acid 28-41 caspase 3 Homo sapiens 216-229 19236754-6 2009 It is concluded that gambogic acid induces the apoptosis of Raji cells through DIO-1 upregulation, nuclear translocation, Bcl-xL downregulation and caspase 3 activation. gambogic acid 21-34 caspase 3 Homo sapiens 148-157 21859709-7 2011 GA activated the three major signaling pathways of the MAPK family, as well as caspase-3, -8, and Poly(ADP-ribose)polymerase apoptotic pathway. gambogic acid 0-2 caspase 3 Homo sapiens 79-88 19200201-0 2009 Gambogic acid induces apoptosis by regulating the expression of Bax and Bcl-2 and enhancing caspase-3 activity in human malignant melanoma A375 cells. gambogic acid 0-13 caspase 3 Homo sapiens 92-101 19200201-10 2009 CONCLUSION: GA can inhibit the proliferation of A375 cells and induce their apoptosis, which may be related to the up-regulation of the Bax/Bcl-2 ratio and caspase-3 activity. gambogic acid 12-14 caspase 3 Homo sapiens 156-165 18298900-8 2008 Treated by GA, the expression of DIO-1 was upregulated, and that of Bcl-2 and NF-kappaB was downregulated, leading to the activation of pro-caspase 3. gambogic acid 11-13 caspase 3 Homo sapiens 136-149 31313541-10 2019 For GA-treated cells, the viability/proliferation loss due to GA was dependent on the expression of CD71 and involved activation of caspase-3 and degradation of EGFR. gambogic acid 4-6 caspase 3 Homo sapiens 132-141 31313541-10 2019 For GA-treated cells, the viability/proliferation loss due to GA was dependent on the expression of CD71 and involved activation of caspase-3 and degradation of EGFR. gambogic acid 62-64 caspase 3 Homo sapiens 132-141 26357974-9 2016 Western blot analysis demonstrated that GA-induced cell cycle arrest and apoptosis in CNE-2 cells was associated with upregulated expression of caspase-3 and Bax and downregulated expression of Bcl-2 and cyclin B1/p-cdc2 in hypoxia. gambogic acid 40-42 caspase 3 Homo sapiens 144-153 30293083-11 2018 GA treatment significantly decreased the expression levels of DLL1, DLL3, DLL4, Jagged1, Jagged2, Bcl2, and PK3K, inhibited NICD nuclear translocation and Akt phosphorylation, and increased expression level of active caspase3. gambogic acid 0-2 caspase 3 Homo sapiens 217-225 30269846-4 2018 Furthermore, GA induced cell death through endoplasmic reticulum stress (ERS) mediated suppression of Akt signaling pathways and finally the release of the caspase-3 proteases. gambogic acid 13-15 caspase 3 Homo sapiens 156-165 26034354-13 2015 Protein levels of apoptosis-related factors Fas, FasL, FADD, cytochrome c, and Apaf-1 were increased in GA-treated cells, whereas levels of pro-caspase-8, -9 and -3 were significantly decreased (P < 0.05 for all). gambogic acid 104-106 caspase 3 Homo sapiens 140-164 26345420-8 2015 CONCLUSION: Fe3O4-MNP can promote GA-induced apoptosis of SMMC-7721 cells, which may be related to the downregulation of Bcl-2 and upregulation of caspase-3. gambogic acid 34-36 caspase 3 Homo sapiens 147-156