PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29050671-0	2017	Gambogic acid improves non-small cell lung cancer progression by inhibition of mTOR signaling pathway.	gambogic acid	0-13	mechanistic target of rapamycin kinase	Homo sapiens	79-83	
31748028-10	2020	These results suggested that downregulation of PI3K/AKT/mTOR signaling pathway may be an important mediator in GA-affected ribosomal occurrence in glioma cells.	gambogic acid	111-113	mechanistic target of rapamycin kinase	Homo sapiens	56-60	
31513784-0	2019	Involvement of E-cadherin/AMPK/mTOR axis in LKB1-induced sensitivity of non-small cell lung cancer to gambogic acid.	gambogic acid	102-115	mechanistic target of rapamycin kinase	Homo sapiens	31-35	
32913452-0	2020	Gambogic acid affects ESCC progression through regulation of PI3K/AKT/mTOR signal pathway.	gambogic acid	0-13	mechanistic target of rapamycin kinase	Homo sapiens	70-74	
32913452-5	2020	Further investigation showed that GA down-regulated the levels of PI3K, p-AKT and p-mTOR, while promoted PTEN expression in ESCC cells.	gambogic acid	34-36	mechanistic target of rapamycin kinase	Homo sapiens	84-88	
31748028-0	2020	Gambogic Acid Affects Ribosomal Occurrence in Glioma Cells by Downregulating the Phosphoinositide Kinase-3/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway.	gambogic acid	0-13	mechanistic target of rapamycin kinase	Homo sapiens	124-153	
31748028-3	2020	In the current study, the effect of GA on phosphoinositide kinase-3 (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway was examined in human U251 glioma cells.	gambogic acid	36-38	mechanistic target of rapamycin kinase	Homo sapiens	98-127	
31748028-3	2020	In the current study, the effect of GA on phosphoinositide kinase-3 (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway was examined in human U251 glioma cells.	gambogic acid	36-38	mechanistic target of rapamycin kinase	Homo sapiens	129-133	
31748028-7	2020	GA decreased the phosphorylation of P38, AKT, and mTOR.	gambogic acid	0-2	mechanistic target of rapamycin kinase	Homo sapiens	50-54	
29050671-6	2017	Western blot analysis showed that GA treatment suppressed the activation of Akt, mTOR, and S6.	gambogic acid	34-36	mechanistic target of rapamycin kinase	Homo sapiens	81-85	
23194187-7	2012	GA also inhibited cell survival via blocking Akt/mTOR signaling.	gambogic acid	0-2	mechanistic target of rapamycin kinase	Homo sapiens	49-53	
26318432-0	2016	Gambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactive oxygen species via targeting Akt/mTOR pathway.	gambogic acid	0-13	mechanistic target of rapamycin kinase	Homo sapiens	131-135	
24890366-7	2014	Mechanistic studies exhibited that GA inhibited the production of HIF-1alpha by reducing phosphorylation of Akt and mTOR in U266 cells.	gambogic acid	35-37	mechanistic target of rapamycin kinase	Homo sapiens	116-120	
24890366-9	2014	Taken together, our results identify that GA suppresses hypoxia-activated pathways that are linked to MM progression, at least partly, by the inhibition of the PI3K/Akt/mTOR signaling pathway.	gambogic acid	42-44	mechanistic target of rapamycin kinase	Homo sapiens	169-173	
24810758-5	2014	Functional studies revealed that GA-induced dysregulation of lipid metabolism could activate 5-lipoxygenase (5-LOX), resulting in intracellular ROS accumulation, followed by inhibition of Akt-mTOR signaling and autophagy initiation.	gambogic acid	33-35	mechanistic target of rapamycin kinase	Homo sapiens	192-196