PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18586278-0 2008 Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells. gambogic acid 103-116 mitogen-activated protein kinase 8 Homo sapiens 52-77 26205493-0 2015 Gambogic acid inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the JNK, p38 and Akt signalling pathways. gambogic acid 0-13 mitogen-activated protein kinase 8 Homo sapiens 100-103 22739161-6 2012 The positive cell number of activated caspase 3, caspase 8, caspase 9 and the levels of activated caspase 3, caspase 9, p-JNK, P38 increased after Jurkat cells were treated with GA. ROS, CaMKII, caspase 3, caspase 9, MAPKK, JNK1/2 and P38 inhibitors had some significant effect on GA-induced apoptosis. gambogic acid 178-180 mitogen-activated protein kinase 8 Homo sapiens 224-230 22739161-8 2012 It is concluded that GA induced apoptosis of Jurkat cells by activated caspases through activating of ROS-CaMKII-MAPKK-JNK/P38 pathway. gambogic acid 21-23 mitogen-activated protein kinase 8 Homo sapiens 119-122 26397804-6 2015 In the present study, we showed that GA directly inhibited proliferation and induced apoptosis in both 5-fluorouracil (5-FU) sensitive and 5-FU resistant colorectal cancer cells; induced apoptosis via activating JNK signaling pathway. gambogic acid 37-39 mitogen-activated protein kinase 8 Homo sapiens 212-215 25887496-0 2015 Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid. gambogic acid 105-118 mitogen-activated protein kinase 8 Homo sapiens 84-87 25887496-12 2015 CONCLUSIONS: These results suggest that GA induce apoptosis associated with the ER stress response through up-regulation of p-JNK and down-regulation of p-ERK in HeLa cells. gambogic acid 40-42 mitogen-activated protein kinase 8 Homo sapiens 126-129 25218692-5 2014 RESULTS: Gambogic acid induces reactive oxygen species, and elicits a strong autophagic response by activating JNK at earlier time points, which is inhibited at later time points with the activation of caspases. gambogic acid 9-22 mitogen-activated protein kinase 8 Homo sapiens 111-114 18923540-6 2008 Additionally, GA exerted an inhibitory effect on the phosphorylation of ERK1/2 and JNK, while it had no effect on p38. gambogic acid 14-16 mitogen-activated protein kinase 8 Homo sapiens 83-86 18586278-6 2008 We also revealed that phosphorylation levels of p38 and c-Jun N-terminal kinase-1 (JNK-1) were increased markedly by GA, resulting in apoptosis of MCF-7 cells. gambogic acid 117-119 mitogen-activated protein kinase 8 Homo sapiens 56-81 18586278-6 2008 We also revealed that phosphorylation levels of p38 and c-Jun N-terminal kinase-1 (JNK-1) were increased markedly by GA, resulting in apoptosis of MCF-7 cells. gambogic acid 117-119 mitogen-activated protein kinase 8 Homo sapiens 83-88 18586278-7 2008 Taken together, our results suggested that GA depolymerized microtubules and elevated the phosphorylation levels of JNK1 and p38, which caused G2/M cell cycle arrest and apoptosis in MCF-7 cells. gambogic acid 43-45 mitogen-activated protein kinase 8 Homo sapiens 116-120