PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26397804-6	2015	In the present study, we showed that GA directly inhibited proliferation and induced apoptosis in both 5-fluorouracil (5-FU) sensitive and 5-FU resistant colorectal cancer cells; induced apoptosis via activating JNK signaling pathway.	gambogic acid	37-39	mitogen-activated protein kinase 8	Homo sapiens	212-215	
25218692-5	2014	RESULTS: Gambogic acid induces reactive oxygen species, and elicits a strong autophagic response by activating JNK at earlier time points, which is inhibited at later time points with the activation of caspases.	gambogic acid	9-22	mitogen-activated protein kinase 8	Homo sapiens	111-114	
22739161-6	2012	The positive cell number of activated caspase 3, caspase 8, caspase 9 and the levels of activated caspase 3, caspase 9, p-JNK, P38 increased after Jurkat cells were treated with GA. ROS, CaMKII, caspase 3, caspase 9, MAPKK, JNK1/2 and P38 inhibitors had some significant effect on GA-induced apoptosis.	gambogic acid	178-180	mitogen-activated protein kinase 8	Homo sapiens	224-230	
22739161-8	2012	It is concluded that GA induced apoptosis of Jurkat cells by activated caspases through activating of ROS-CaMKII-MAPKK-JNK/P38 pathway.	gambogic acid	21-23	mitogen-activated protein kinase 8	Homo sapiens	119-122	
18923540-6	2008	Additionally, GA exerted an inhibitory effect on the phosphorylation of ERK1/2 and JNK, while it had no effect on p38.	gambogic acid	14-16	mitogen-activated protein kinase 8	Homo sapiens	83-86	
18586278-0	2008	Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells.	gambogic acid	103-116	mitogen-activated protein kinase 8	Homo sapiens	52-77	
18586278-6	2008	We also revealed that phosphorylation levels of p38 and c-Jun N-terminal kinase-1 (JNK-1) were increased markedly by GA, resulting in apoptosis of MCF-7 cells.	gambogic acid	117-119	mitogen-activated protein kinase 8	Homo sapiens	56-81	
18586278-6	2008	We also revealed that phosphorylation levels of p38 and c-Jun N-terminal kinase-1 (JNK-1) were increased markedly by GA, resulting in apoptosis of MCF-7 cells.	gambogic acid	117-119	mitogen-activated protein kinase 8	Homo sapiens	83-88	
18586278-7	2008	Taken together, our results suggested that GA depolymerized microtubules and elevated the phosphorylation levels of JNK1 and p38, which caused G2/M cell cycle arrest and apoptosis in MCF-7 cells.	gambogic acid	43-45	mitogen-activated protein kinase 8	Homo sapiens	116-120	
26205493-0	2015	Gambogic acid inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the JNK, p38 and Akt signalling pathways.	gambogic acid	0-13	mitogen-activated protein kinase 8	Homo sapiens	100-103	
25887496-0	2015	Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid.	gambogic acid	105-118	mitogen-activated protein kinase 8	Homo sapiens	84-87	
25887496-12	2015	CONCLUSIONS: These results suggest that GA induce apoptosis associated with the ER stress response through up-regulation of p-JNK and down-regulation of p-ERK in HeLa cells.	gambogic acid	40-42	mitogen-activated protein kinase 8	Homo sapiens	126-129