PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27473145-5 2016 However, combined treatment with GA and CDDP revealed a strong synergistic action between these drugs, and higher protein levels of the apoptosis-related factor Fas, cleaved caspase-8 and cleaved caspase-3 and lower expression of hypoxia-inducible factor (HIF)-1alpha are detected in both cell lines. gambogic acid 33-35 caspase 8 Homo sapiens 174-183 26034354-12 2015 Levels of caspase-8, -9 and -3 mRNAs were significantly increased after treatment with GA (1.25, 2.50 or 5.00 mumol/L) for 48 h (P < 0.05 for all). gambogic acid 87-89 caspase 8 Homo sapiens 10-30 23426995-6 2013 The results suggest that both the caspases in the extrinsic death receptor pathway and the mitochondrial-dependent pathway are involved in the GA-induced cell apoptosis. gambogic acid 143-145 caspase 8 Homo sapiens 34-42 22739161-6 2012 The positive cell number of activated caspase 3, caspase 8, caspase 9 and the levels of activated caspase 3, caspase 9, p-JNK, P38 increased after Jurkat cells were treated with GA. ROS, CaMKII, caspase 3, caspase 9, MAPKK, JNK1/2 and P38 inhibitors had some significant effect on GA-induced apoptosis. gambogic acid 178-180 caspase 8 Homo sapiens 49-58 22739161-8 2012 It is concluded that GA induced apoptosis of Jurkat cells by activated caspases through activating of ROS-CaMKII-MAPKK-JNK/P38 pathway. gambogic acid 21-23 caspase 8 Homo sapiens 71-79 17426447-0 2007 Caspase-8 preferentially senses the apoptosis-inducing action of NG-18, a Gambogic acid derivative, in human leukemia HL-60 cells. gambogic acid 74-87 caspase 8 Homo sapiens 0-9 23194187-5 2012 Furthermore, GA induced PARP cleavage, activation of caspase-3, caspase-8, and caspase-9, as well as an increased ratio of Bax/Bcl-2. gambogic acid 13-15 caspase 8 Homo sapiens 64-73 20030923-10 2009 GA could decrease the mitochondrial membrane potential and increase the activated caspase 3, caspase 8, caspase 9 positive cell levels by 2.19%, -1.95%, 34.01% in 24 hr and 60.4%, 71.3%, 77.7% in 48 hr respectively. gambogic acid 0-2 caspase 8 Homo sapiens 93-102