PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27473145-5	2016	However, combined treatment with GA and CDDP revealed a strong synergistic action between these drugs, and higher protein levels of the apoptosis-related factor Fas, cleaved caspase-8 and cleaved caspase-3 and lower expression of hypoxia-inducible factor (HIF)-1alpha are detected in both cell lines.	gambogic acid	33-35	caspase 8	Homo sapiens	174-183	
23426995-6	2013	The results suggest that both the caspases in the extrinsic death receptor pathway and the mitochondrial-dependent pathway are involved in the GA-induced cell apoptosis.	gambogic acid	143-145	caspase 8	Homo sapiens	34-42	
26034354-12	2015	Levels of caspase-8, -9 and -3 mRNAs were significantly increased after treatment with GA (1.25, 2.50 or 5.00 mumol/L) for 48 h (P < 0.05 for all).	gambogic acid	87-89	caspase 8	Homo sapiens	10-30	
23194187-5	2012	Furthermore, GA induced PARP cleavage, activation of caspase-3, caspase-8, and caspase-9, as well as an increased ratio of Bax/Bcl-2.	gambogic acid	13-15	caspase 8	Homo sapiens	64-73	
20030923-10	2009	GA could decrease the mitochondrial membrane potential and increase the activated caspase 3, caspase 8, caspase 9 positive cell levels by 2.19%, -1.95%, 34.01% in 24 hr and 60.4%, 71.3%, 77.7% in 48 hr respectively.	gambogic acid	0-2	caspase 8	Homo sapiens	93-102	
22739161-6	2012	The positive cell number of activated caspase 3, caspase 8, caspase 9 and the levels of activated caspase 3, caspase 9, p-JNK, P38 increased after Jurkat cells were treated with GA. ROS, CaMKII, caspase 3, caspase 9, MAPKK, JNK1/2 and P38 inhibitors had some significant effect on GA-induced apoptosis.	gambogic acid	178-180	caspase 8	Homo sapiens	49-58	
22739161-8	2012	It is concluded that GA induced apoptosis of Jurkat cells by activated caspases through activating of ROS-CaMKII-MAPKK-JNK/P38 pathway.	gambogic acid	21-23	caspase 8	Homo sapiens	71-79	
17426447-0	2007	Caspase-8 preferentially senses the apoptosis-inducing action of NG-18, a Gambogic acid derivative, in human leukemia HL-60 cells.	gambogic acid	74-87	caspase 8	Homo sapiens	0-9