PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15963007-13 2005 In contrast, sulphonylureas, meglitinide derivatives and thiazolidinediones are extensively metabolised in the liver via the CYP system and thus, may be subject to drug-drug metabolic interactions. meglitinide 29-40 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 125-128 27722966-13 2005 In contrast, sulphonylureas, meglitinide derivatives and thiazolidinediones are extensively metabolised in the liver via the CYP system and thus, may be subject to drug-drug metabolic interactions. meglitinide 29-40 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 125-128 27722966-20 2005 Significantly increased (with CYP inhibitors) or decreased (with CYP inducers) plasma levels of sulphonylureas, meglitinide derivatives and thiazolidinediones have been reported in healthy volunteers, and these pharmacokinetic changes may lead to enhanced or reduced glucose-lowering action, and thus hypoglycaemia or worsening of metabolic control, respectively. meglitinide 112-123 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-68 15963007-21 2005 Significantly increased (with CYP inhibitors) or decreased (with CYP inducers) plasma levels of sulphonylureas, meglitinide derivatives and thiazolidinediones have been reported in healthy volunteers, and these pharmacokinetic changes may lead to enhanced or reduced glucose-lowering action, and thus hypoglycaemia or worsening of metabolic control, respectively. meglitinide 112-123 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-68 30181852-0 2018 Drug interactions of meglitinide antidiabetics involving CYP enzymes and OATP1B1 transporter. meglitinide 21-32 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 57-60 30181852-3 2018 Meglitinides are the substrates of cytochrome P450 (CYP) enzymes and organic anion transporting polypeptide 1B1 (OATP1B1 transporter) and the coadministration of the drugs affecting them will result in pharmacokinetic drug interactions. meglitinide 0-12 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 35-50 30181852-3 2018 Meglitinides are the substrates of cytochrome P450 (CYP) enzymes and organic anion transporting polypeptide 1B1 (OATP1B1 transporter) and the coadministration of the drugs affecting them will result in pharmacokinetic drug interactions. meglitinide 0-12 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 52-55 30181852-4 2018 This article focuses on the drug interactions of meglitinides involving CYP enzymes and OATP1B1 transporter. meglitinide 49-61 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-75