PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24777815-1 2014 In gastrointestinal smooth muscle, agonists that bind to Gi-coupled receptors activate preferentially PLC-beta3 via Gbetagamma to stimulate phosphoinositide (PI) hydrolysis and generate inositol 1,4,5-trisphosphate (IP3) leading to IP3-dependent Ca(2+) release and muscle contraction. gbetagamma 116-126 phospholipase C beta 3 Homo sapiens 102-111 24578342-1 2014 Others and we have characterized several Gbetagamma-dependent effectors in smooth muscle, including G protein-coupled receptor kinase 2 (GRK2), PLCbeta3, and phosphatidylinositol (PI) 3-kinase-gamma, and have identified various signaling targets downstream of PI 3-kinase-gamma, including cSrc, integrin-linked kinase, and Rac1-Cdc42/p21-activated kinase/p38 MAP kinase. gbetagamma 41-51 phospholipase C beta 3 Homo sapiens 144-152 11325525-3 2001 The inhibitory effect of KN-93 was also observed when PLCbeta3 was stimulated directly by Galphaq or Gbetagamma in overexpression assays. gbetagamma 101-111 phospholipase C beta 3 Homo sapiens 54-62 10893237-4 2000 The PKC inhibitory effect was also observed when PLCbeta(3) was stimulated directly by Galpha(q) or Gbetagamma in overexpression assays. gbetagamma 100-110 phospholipase C beta 3 Homo sapiens 49-59