PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21501142-5 2011 KEY RESULTS: Low concentrations of celastrol completely inhibited NOX1, NOX2, NOX4 and NOX5 within minutes with concentration-response curves exhibiting higher Hill coefficients and lower IC50 values for NOX1 and NOX2 compared with NOX4 and NOX5, suggesting differences in their mode of action. celastrol 35-44 NADPH oxidase 5 Homo sapiens 87-91 21501142-5 2011 KEY RESULTS: Low concentrations of celastrol completely inhibited NOX1, NOX2, NOX4 and NOX5 within minutes with concentration-response curves exhibiting higher Hill coefficients and lower IC50 values for NOX1 and NOX2 compared with NOX4 and NOX5, suggesting differences in their mode of action. celastrol 35-44 NADPH oxidase 5 Homo sapiens 241-245 21501142-6 2011 In a cell-free system, celastrol had an IC50 of 1.24 and 8.4 microM for NOX2 and NOX5, respectively. celastrol 23-32 NADPH oxidase 5 Homo sapiens 81-85