PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33831397-0 2021 Homoharringtonine synergizes with quizartinib in FLT3-ITD acute myeloid leukemia by targeting FLT3-AKT-c-Myc pathway. quizartinib 34-45 MYC proto-oncogene, bHLH transcription factor Homo sapiens 103-108 33831397-6 2021 Mechanistically, HHT and quizartinib cooperatively inhibit FLT3-AKT and its downstream targets GSK3beta, c-Myc, and cyclin D1, cooperatively up-regulate the pro-apoptosis proteins Bim and Bax, and down-regulate the anti-apoptosis protein Mcl1. quizartinib 25-36 MYC proto-oncogene, bHLH transcription factor Homo sapiens 105-110