PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25487917-8	2015	However, when AC220 was combined with the CDK4 inhibitor PD0332991 (palbociclib) at 0.1 mumol/L or higher, no resistance mutations were obtained, indicating that the CDK4-inhibiting activity of AMG 925 contributed to the failure to develop drug resistance.	quizartinib	14-19	cyclin dependent kinase 4	Homo sapiens	166-170