PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8654206-0 1995 Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193. zileuton 88-96 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 34-49 8654206-1 1995 In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) forms involved in the oxidative metabolism of [14C]zileuton (ABT-077) and its N-dehydroxylated metabolite, [14C]Abbott-66193, by human liver microsomes. zileuton 129-137 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 56-71 8654206-1 1995 In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) forms involved in the oxidative metabolism of [14C]zileuton (ABT-077) and its N-dehydroxylated metabolite, [14C]Abbott-66193, by human liver microsomes. zileuton 129-137 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 73-76 8654206-3 1995 Results suggested that whereas the metabolism of zileuton and Abbott-66193 were mediated by the same CYP forms, the CYP forms responsible for hydroxylation (CYP1A2 and CYP2C9/10) were distinct from those involved in sulfoxidation (CYP3A > CYP2C9/10). zileuton 49-57 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 101-104