PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24021192-9	2013	Zileuton inhibited an OA-stimulated increase in ASM by inhibiting hypertrophy, hyperplasia and increased extracellular matrix via the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, thereby reducing cyclin D1 expression and attenuating bronchial hyperresponsiveness.	zileuton	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	171-174	
27380038-0	2016	5-LOX Inhibitor Zileuton Reduces Inflammatory Reaction and Ischemic Brain Damage Through the Activation of PI3K/Akt Signaling Pathway.	zileuton	16-24	AKT serine/threonine kinase 1	Rattus norvegicus	112-115	
27380038-2	2016	However, it was elusive whether zileuton attenuates inflammatory reaction and ischemic brain damage through the modulation of PI3K/Akt signaling pathway.	zileuton	32-40	AKT serine/threonine kinase 1	Rattus norvegicus	131-134	
27380038-3	2016	In the present study, we, for the first time, investigated whether PI3K/Akt pathway was involved in zileuton"s anti-inflammatory and neuroprotective properties against brain damage following experimental ischemic stroke.	zileuton	100-108	AKT serine/threonine kinase 1	Rattus norvegicus	72-75	
27380038-12	2016	Zileuton significantly up-regulates the expression of p-Akt, which was inhibited by LY294002 administration.	zileuton	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	56-59	
24021192-11	2013	Zileuton effectively prevents bronchial hyperresponsiveness, airway inflammation and ASM remodeling in sensitized rats through the PI3K/Akt pathway, which reduces cyclin D1 expression.	zileuton	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	136-139	
19781629-9	2010	Furthermore, zileuton-stimulated ERK1/2 and Akt phosphorylation was attenuated by rottlerin, indicating that PKC delta might act upstream of ERK1/2 and Akt.	zileuton	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	44-47	
19781629-9	2010	Furthermore, zileuton-stimulated ERK1/2 and Akt phosphorylation was attenuated by rottlerin, indicating that PKC delta might act upstream of ERK1/2 and Akt.	zileuton	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	152-155	
19781629-10	2010	Moreover, inhibition of either ERK1/2 or Akt activation abolished zileuton-induced COX-2 expression.	zileuton	66-74	AKT serine/threonine kinase 1	Rattus norvegicus	41-44	
19781629-12	2010	These results suggest that zileuton-induced COX-2 expression is sequentially mediated through PKC delta-dependent activation of ERK1/2 and Akt.	zileuton	27-35	AKT serine/threonine kinase 1	Rattus norvegicus	139-142	
33878031-4	2021	Zileuton and LY294002 were used to inhibit expression of 5-LOX and Akt, respectively.	zileuton	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	67-70	
33878031-7	2021	Zileuton also upregulated activated (phosphorylated) AKT levels, and these beneficial effects of Zileuton were abolished by intracerebroventricular infusion of the PI3K inhibitor LY294002.	zileuton	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	53-56