PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21544450-6 1996 Our results point to additional, as yet unidentified factors beyond the expression levels of P-glycoprotein which could contribute to the susceptibility of MDR cells to a combined treatment using taxanes and different chemosensitizing compounds. Taxoids 196-203 ATP binding cassette subfamily B member 1 Homo sapiens 93-107 29675746-0 2018 Cabazitaxel is more active than first-generation taxanes in ABCB1(+) cell lines due to its reduced affinity for P-glycoprotein. Taxoids 49-56 ATP binding cassette subfamily B member 1 Homo sapiens 60-65 34126072-1 2021 Multidrug resistance-associated protein 7 (MRP7) is an important member of ABC transporter superfamily and has been revealed to mediate the cross-membrane translocation of a wide range of chemotherapeutic agents including taxanes, epothilones, Vinca alkaloids, Anthracyclines and Epipodophyllotoxins.In our previous study, a 1,2,3-triazole-pyrimidine hybridCMP25was synthesized and found able to efficiently reverse multidrug resistance (MDR) mediated by P-glycoprotein. Taxoids 222-229 ATP binding cassette subfamily B member 1 Homo sapiens 455-469 33649523-9 2021 Despite the population was heterogeneous, CYP3A4*22 and CYP2C8 SNPs may influence paclitaxel and nab-paclitaxel toxicity and ABCB1 c.3435 may affect taxanes effectiveness, even if any statistically significant was found. Taxoids 149-156 ATP binding cassette subfamily B member 1 Homo sapiens 125-130 31075528-9 2019 Upregulated ABCB1 mediates cross-resistance between taxanes and olaparib, which can be overcome through decreasing ABCB1 expression or inhibiting ABCB1 using elacridar or enzalutamide. Taxoids 52-59 ATP binding cassette subfamily B member 1 Homo sapiens 12-17 31075528-9 2019 Upregulated ABCB1 mediates cross-resistance between taxanes and olaparib, which can be overcome through decreasing ABCB1 expression or inhibiting ABCB1 using elacridar or enzalutamide. Taxoids 52-59 ATP binding cassette subfamily B member 1 Homo sapiens 115-120 31075528-9 2019 Upregulated ABCB1 mediates cross-resistance between taxanes and olaparib, which can be overcome through decreasing ABCB1 expression or inhibiting ABCB1 using elacridar or enzalutamide. Taxoids 52-59 ATP binding cassette subfamily B member 1 Homo sapiens 115-120 31181726-1 2019 A series of novel 7,9-O-linked macrocyclic taxoids together with modification at the C2 position were synthesized, and their cytotoxicities against drug-sensitive and P-glycoprotein and betaIII-tubulin overexpressed drug-resistant cancer cell lines were evaluated. Taxoids 43-50 ATP binding cassette subfamily B member 1 Homo sapiens 167-181 32749138-3 2020 Taxanes have low bioavailability, are extensively metabolized by CYP3A, and have a high affinity for P-glycoprotein. Taxoids 0-7 ATP binding cassette subfamily B member 1 Homo sapiens 101-115 29675746-0 2018 Cabazitaxel is more active than first-generation taxanes in ABCB1(+) cell lines due to its reduced affinity for P-glycoprotein. Taxoids 49-56 ATP binding cassette subfamily B member 1 Homo sapiens 112-126 29861877-5 2018 Contrasting results, however, have been reported on the capability of variants of other genes as MTHFR, TYMS, ERCC1, XRCC1, GSTP1, CYP3A4/3A5 and ABCB1, in predicting either therapy efficacy or toxicity in patients undergoing treatment with pyrimidine antimetabolites, platinum derivatives, irinotecan and taxanes. Taxoids 306-313 ATP binding cassette subfamily B member 1 Homo sapiens 146-151 29625142-6 2018 The increase in the ATPase activity of ABCB1 transporter after the application of taxanes from the first group was found to be somewhat higher than after the application of taxanes from the third group. Taxoids 82-89 ATP binding cassette subfamily B member 1 Homo sapiens 39-44 29625142-6 2018 The increase in the ATPase activity of ABCB1 transporter after the application of taxanes from the first group was found to be somewhat higher than after the application of taxanes from the third group. Taxoids 173-180 ATP binding cassette subfamily B member 1 Homo sapiens 39-44 27868228-9 2017 IMPLICATIONS FOR THERAPY: Amiodarone inhibits cytochrome P450 (CYP) isoforms 2C8 and 3A4 as well as P-glycoprotein (P-gp) for which taxanes are substrates. Taxoids 132-139 ATP binding cassette subfamily B member 1 Homo sapiens 100-114 28624703-0 2017 Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by betaIII-Tubulin and P-glycoprotein (P-gp) overexpressions. Taxoids 23-30 ATP binding cassette subfamily B member 1 Homo sapiens 172-186 28624703-0 2017 Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by betaIII-Tubulin and P-glycoprotein (P-gp) overexpressions. Taxoids 23-30 ATP binding cassette subfamily B member 1 Homo sapiens 188-192 28476838-2 2017 Taxanes are metabolized in human liver by the cytochrome CYP3A and are substrate of ATP-binding cassette multidrug transporters ABCB1. Taxoids 0-7 ATP binding cassette subfamily B member 1 Homo sapiens 128-133 28476838-8 2017 CONCLUSION: ABCB1 3435 T/T seems to be associated to lower rate of toxicity in patients receiving taxanes. Taxoids 98-105 ATP binding cassette subfamily B member 1 Homo sapiens 12-17 29517223-1 2018 Several next-generation taxanes have been reported to possess high potency against Taxol-resistant cancer cell lines overexpressing betaIII-tubulin and/or P-glycoprotein (P-gp), both of which are involved in drug resistance. Taxoids 24-31 ATP binding cassette subfamily B member 1 Homo sapiens 155-169 29517223-1 2018 Several next-generation taxanes have been reported to possess high potency against Taxol-resistant cancer cell lines overexpressing betaIII-tubulin and/or P-glycoprotein (P-gp), both of which are involved in drug resistance. Taxoids 24-31 ATP binding cassette subfamily B member 1 Homo sapiens 171-175 29517223-5 2018 Distinct potencies of the two taxanes against different MSA-resistant cells expressing unique levels of MDR1 and betaIII-tubulin were found. Taxoids 30-37 ATP binding cassette subfamily B member 1 Homo sapiens 104-108 29441783-1 2018 Next-generation taxoids, such as SB-T-1214, are highly potent cytotoxic agents that exhibit remarkable efficacy against drug-resistant tumors in vivo, including those that overexpress the P-glycoprotein (Pgp) efflux pump. Taxoids 16-23 ATP binding cassette subfamily B member 1 Homo sapiens 188-202 29441783-1 2018 Next-generation taxoids, such as SB-T-1214, are highly potent cytotoxic agents that exhibit remarkable efficacy against drug-resistant tumors in vivo, including those that overexpress the P-glycoprotein (Pgp) efflux pump. Taxoids 16-23 ATP binding cassette subfamily B member 1 Homo sapiens 204-207 28941201-6 2017 However, these agents were able to overcome multidrug resistance, as they were virtually unrecognized by ABCB1, a major cellular exporter of taxanes. Taxoids 141-148 ATP binding cassette subfamily B member 1 Homo sapiens 105-110 27868228-9 2017 IMPLICATIONS FOR THERAPY: Amiodarone inhibits cytochrome P450 (CYP) isoforms 2C8 and 3A4 as well as P-glycoprotein (P-gp) for which taxanes are substrates. Taxoids 132-139 ATP binding cassette subfamily B member 1 Homo sapiens 116-120 28642838-5 2016 In regards to the taxanes, one of the key contributors to drug resistance is increased drug efflux through ATP Binding Cassette Subfamily B Member 1 (ABCB1). Taxoids 18-25 ATP binding cassette subfamily B member 1 Homo sapiens 107-148 28642838-5 2016 In regards to the taxanes, one of the key contributors to drug resistance is increased drug efflux through ATP Binding Cassette Subfamily B Member 1 (ABCB1). Taxoids 18-25 ATP binding cassette subfamily B member 1 Homo sapiens 150-155 27727250-0 2016 Notch-1 Confers Chemoresistance in Lung Adenocarcinoma to Taxanes through AP-1/microRNA-451 Mediated Regulation of MDR-1. Taxoids 58-65 ATP binding cassette subfamily B member 1 Homo sapiens 115-120 25685543-5 2015 Accordingly, P-gp inhibitors/blockers are potential enhancer for the cellular bioavailability of several clinically important anticancer drugs such as, anthracyclines, taxanes, vinca alkaloids, and podophyllotoxins. Taxoids 168-175 ATP binding cassette subfamily B member 1 Homo sapiens 13-17 27725879-2 2016 In the present study, we applied the CRISPR/Cas9 system to target ABCB1 (also named MDR1) gene which encodes a 170 kDa transmembrane glycoprotein (P-glycoprotein/P-gp) transporting multiple types of chemotherapeutic drugs including taxanes, epipodophyllotoxins, vinca alkaloids and anthracyclines out of cells to contribute multidrug resistance (MDR) in cancer cells. Taxoids 232-239 ATP binding cassette subfamily B member 1 Homo sapiens 66-71 27725879-2 2016 In the present study, we applied the CRISPR/Cas9 system to target ABCB1 (also named MDR1) gene which encodes a 170 kDa transmembrane glycoprotein (P-glycoprotein/P-gp) transporting multiple types of chemotherapeutic drugs including taxanes, epipodophyllotoxins, vinca alkaloids and anthracyclines out of cells to contribute multidrug resistance (MDR) in cancer cells. Taxoids 232-239 ATP binding cassette subfamily B member 1 Homo sapiens 84-88 27574448-4 2016 We evaluated the relationship between neurotoxicity of taxanes and single-nucleotide polymorphisms of ABCB1, CYP3A4, ERCC1, ERCC2, FGFR4, TP53, ERBB2, and CYP2C8 genes. Taxoids 55-62 ATP binding cassette subfamily B member 1 Homo sapiens 102-107 24704000-1 2014 Polymorphisms in genes encoding CYPs (Phase I) and ABCB1 (Phase III) enzymes may attribute to variability of efficacy of taxanes. Taxoids 121-128 ATP binding cassette subfamily B member 1 Homo sapiens 51-56 24704000-2 2014 The present study aims to find the influence of CYP and ABCB1 gene polymorphisms on taxanes based clinical outcomes. Taxoids 84-91 ATP binding cassette subfamily B member 1 Homo sapiens 56-61 24447372-13 2014 The high expression level of ABCB1, the specific composition and localization of beta-tubulin isoforms, the weak microtubule dynamics and its insensitivity to docetaxel may all contribute to the acquired resistance of MCF-7TXT cells to taxanes. Taxoids 236-243 ATP binding cassette subfamily B member 1 Homo sapiens 29-34 24332858-1 2014 A group of novel taxoids, with modifications at C-7, C-10, C-3" and C-14 positions of paclitaxel, was synthesized in order to improve their biological profile by decreasing their affinity with P-glycoprotein (P-gp) and increasing cellular permeability. Taxoids 17-24 ATP binding cassette subfamily B member 1 Homo sapiens 193-207 24332858-1 2014 A group of novel taxoids, with modifications at C-7, C-10, C-3" and C-14 positions of paclitaxel, was synthesized in order to improve their biological profile by decreasing their affinity with P-glycoprotein (P-gp) and increasing cellular permeability. Taxoids 17-24 ATP binding cassette subfamily B member 1 Homo sapiens 209-213 21618519-0 2012 Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1. Taxoids 57-64 ATP binding cassette subfamily B member 1 Homo sapiens 101-123 21374643-2 2012 Cellular overproduction of P-glycoprotein (P-gp), which acts as an efflux pump for various anticancer drugs (e.g. anthracyclines, Vinca alkaloids, taxanes, epipodophyllotoxins, and some of the newer antitumor drugs) is one of the more relevant mechanisms underlying MDR. Taxoids 147-154 ATP binding cassette subfamily B member 1 Homo sapiens 27-41 21374643-2 2012 Cellular overproduction of P-glycoprotein (P-gp), which acts as an efflux pump for various anticancer drugs (e.g. anthracyclines, Vinca alkaloids, taxanes, epipodophyllotoxins, and some of the newer antitumor drugs) is one of the more relevant mechanisms underlying MDR. Taxoids 147-154 ATP binding cassette subfamily B member 1 Homo sapiens 43-47 24344919-1 2013 BACKGROUND: Multidrug resistance 1 (MDR1) gene encodes for an ATP binding cassette transporter--P-glycoprotein (P-gp)-- involved in chemoresistance to taxanes. Taxoids 151-158 ATP binding cassette subfamily B member 1 Homo sapiens 12-34 24344919-1 2013 BACKGROUND: Multidrug resistance 1 (MDR1) gene encodes for an ATP binding cassette transporter--P-glycoprotein (P-gp)-- involved in chemoresistance to taxanes. Taxoids 151-158 ATP binding cassette subfamily B member 1 Homo sapiens 36-40 22855252-3 2012 Structural modifications of taxanes can reduce their P-glycoprotein-related efflux or decrease metabolism and consequently increase taxane efficiency. Taxoids 28-35 ATP binding cassette subfamily B member 1 Homo sapiens 53-67 22855252-10 2012 Thus, structural modifications of taxanes resulting in their decreased P-glycoprotein-related transport probably caused their higher efficiency than paclitaxel in multidrug-resistant NCI/ADR-RES tumour cells. Taxoids 34-41 ATP binding cassette subfamily B member 1 Homo sapiens 71-85 21448449-6 2011 Cancer cells that express P-gp become resistant to taxanes, and the effectiveness of docetaxel can be limited by its high substrate affinity for P-gp. Taxoids 51-58 ATP binding cassette subfamily B member 1 Homo sapiens 26-30 21680190-2 2011 recently reported a novel series of 2-amino-4-methyl-5-phenylethyl substituted-7-benzyl-pyrrolo[2,3-d]pyrimidines, some of which exhibited two digit nanomolar antitumor and antimitotic activity and were not subject to P-glycoprotein (Pgp) or multidrug resistance protein 1 (MRP1) mediated tumor resistance (unlike the Vinca alkaloids and taxanes). Taxoids 338-345 ATP binding cassette subfamily B member 1 Homo sapiens 218-232 21680190-2 2011 recently reported a novel series of 2-amino-4-methyl-5-phenylethyl substituted-7-benzyl-pyrrolo[2,3-d]pyrimidines, some of which exhibited two digit nanomolar antitumor and antimitotic activity and were not subject to P-glycoprotein (Pgp) or multidrug resistance protein 1 (MRP1) mediated tumor resistance (unlike the Vinca alkaloids and taxanes). Taxoids 338-345 ATP binding cassette subfamily B member 1 Homo sapiens 234-237 21680190-2 2011 recently reported a novel series of 2-amino-4-methyl-5-phenylethyl substituted-7-benzyl-pyrrolo[2,3-d]pyrimidines, some of which exhibited two digit nanomolar antitumor and antimitotic activity and were not subject to P-glycoprotein (Pgp) or multidrug resistance protein 1 (MRP1) mediated tumor resistance (unlike the Vinca alkaloids and taxanes). Taxoids 338-345 ATP binding cassette subfamily B member 1 Homo sapiens 242-272 21680190-2 2011 recently reported a novel series of 2-amino-4-methyl-5-phenylethyl substituted-7-benzyl-pyrrolo[2,3-d]pyrimidines, some of which exhibited two digit nanomolar antitumor and antimitotic activity and were not subject to P-glycoprotein (Pgp) or multidrug resistance protein 1 (MRP1) mediated tumor resistance (unlike the Vinca alkaloids and taxanes). Taxoids 338-345 ATP binding cassette subfamily B member 1 Homo sapiens 274-278 21448449-6 2011 Cancer cells that express P-gp become resistant to taxanes, and the effectiveness of docetaxel can be limited by its high substrate affinity for P-gp. Taxoids 51-58 ATP binding cassette subfamily B member 1 Homo sapiens 145-149 24900226-0 2010 From taxuspine x to structurally simplified taxanes with remarkable p-glycoprotein inhibitory activity. Taxoids 44-51 ATP binding cassette subfamily B member 1 Homo sapiens 68-82 20944127-1 2010 BACKGROUND: The transport protein P-glycoprotein, which is encoded by the multidrug-resistance ABCB1 gene, is crucially involved in the export of taxanes and other cytotoxic substances out of the cell. Taxoids 146-153 ATP binding cassette subfamily B member 1 Homo sapiens 34-48 20944127-1 2010 BACKGROUND: The transport protein P-glycoprotein, which is encoded by the multidrug-resistance ABCB1 gene, is crucially involved in the export of taxanes and other cytotoxic substances out of the cell. Taxoids 146-153 ATP binding cassette subfamily B member 1 Homo sapiens 95-100 24900226-1 2010 Three simplified "non-natural" natural taxanes, related to taxuspine X, were synthetized and assayed as P-glycoprotein (P-gp) inhibitors. Taxoids 39-46 ATP binding cassette subfamily B member 1 Homo sapiens 104-118 24900226-1 2010 Three simplified "non-natural" natural taxanes, related to taxuspine X, were synthetized and assayed as P-glycoprotein (P-gp) inhibitors. Taxoids 39-46 ATP binding cassette subfamily B member 1 Homo sapiens 120-124 24900226-3 2010 This model represents the first example of a pharmacophore, which describes interactions of taxanes with P-gp. Taxoids 92-99 ATP binding cassette subfamily B member 1 Homo sapiens 105-109 19401306-1 2010 BACKGROUND: P-glycoprotein (Pgp) is a drug efflux pump that transports natural products, including taxanes and other chemotherapeutic agents, from cells. Taxoids 99-106 ATP binding cassette subfamily B member 1 Homo sapiens 12-26 20374029-6 2010 This article highlights the clinical use of determination of polymorphisms of important human drug-metabolizing cytochrome P450s, ABCB1, IgG fragment C receptors and vascular endothelial growth factor, which are responsible of the large inter-individual variability in drug metabolism and clearance of the agents commonly used in breast cancer treatment, such as tamoxifen, aromatase inhibitors, taxanes, trastuzumab and bevacizumab. Taxoids 396-403 ATP binding cassette subfamily B member 1 Homo sapiens 130-135 19401306-1 2010 BACKGROUND: P-glycoprotein (Pgp) is a drug efflux pump that transports natural products, including taxanes and other chemotherapeutic agents, from cells. Taxoids 99-106 ATP binding cassette subfamily B member 1 Homo sapiens 28-31 19401306-9 2010 Other trials of ABCB1 genotyping in breast and prostate cancer patients receiving taxanes have shown inconsistent results. Taxoids 82-89 ATP binding cassette subfamily B member 1 Homo sapiens 16-21 14981994-8 2003 The strong placental expression of P-glycoprotein may play a major role in limiting fetal exposure to anthracyclines and taxanes. Taxoids 121-128 ATP binding cassette subfamily B member 1 Homo sapiens 35-49 18559268-5 2008 Taxanes with affinities for microtubules well above their affinities for P-glycoprotein are shown not to be affected by multidrug resistance. Taxoids 0-7 ATP binding cassette subfamily B member 1 Homo sapiens 73-87 17620438-1 2007 The multidrug resistance gene 1 (MDR1) product, P-glycoprotein (P-gp), pumps out a variety of anticancer agents from the cell, including anthracyclines, Vinca alkaloids, and taxanes. Taxoids 174-181 ATP binding cassette subfamily B member 1 Homo sapiens 4-31 17620438-1 2007 The multidrug resistance gene 1 (MDR1) product, P-glycoprotein (P-gp), pumps out a variety of anticancer agents from the cell, including anthracyclines, Vinca alkaloids, and taxanes. Taxoids 174-181 ATP binding cassette subfamily B member 1 Homo sapiens 33-37 17620438-1 2007 The multidrug resistance gene 1 (MDR1) product, P-glycoprotein (P-gp), pumps out a variety of anticancer agents from the cell, including anthracyclines, Vinca alkaloids, and taxanes. Taxoids 174-181 ATP binding cassette subfamily B member 1 Homo sapiens 48-62 17620438-1 2007 The multidrug resistance gene 1 (MDR1) product, P-glycoprotein (P-gp), pumps out a variety of anticancer agents from the cell, including anthracyclines, Vinca alkaloids, and taxanes. Taxoids 174-181 ATP binding cassette subfamily B member 1 Homo sapiens 64-68 16842217-10 2006 Also anticancer drugs that belong structurally to classes of drugs extruded from cells by P-gp but that are not substrates of this drug transporter may act as potent inhibitors of MDR tumors (e.g. epothilones, second generation taxanes). Taxoids 228-235 ATP binding cassette subfamily B member 1 Homo sapiens 90-94 15457126-1 2004 The expression of P-glycoprotein (P-gp) has been demonstrated to confer resistance to several anticancer drugs, including anthracyclines, taxanes and vinca alkaloids. Taxoids 138-145 ATP binding cassette subfamily B member 1 Homo sapiens 18-32 15457126-1 2004 The expression of P-glycoprotein (P-gp) has been demonstrated to confer resistance to several anticancer drugs, including anthracyclines, taxanes and vinca alkaloids. Taxoids 138-145 ATP binding cassette subfamily B member 1 Homo sapiens 34-38 15060738-1 2004 PURPOSE: The taxanes paclitaxel and docetaxel are substrates for P-glycoprotein (Pgp), an ATP-binding cassette (ABC) transport protein associated with multidrug resistance (MDR). Taxoids 13-20 ATP binding cassette subfamily B member 1 Homo sapiens 65-79 15060738-1 2004 PURPOSE: The taxanes paclitaxel and docetaxel are substrates for P-glycoprotein (Pgp), an ATP-binding cassette (ABC) transport protein associated with multidrug resistance (MDR). Taxoids 13-20 ATP binding cassette subfamily B member 1 Homo sapiens 81-84 15152938-2 2004 Taxanes are substrates for Pgp and MRP-1, but not BCRP. Taxoids 0-7 ATP binding cassette subfamily B member 1 Homo sapiens 27-30 19442049-1 2009 P-glycoprotein (Pgp), coded for by the mdr1 gene, is one of the ABC transporters held responsible for the phenomenon of multidrug resistance (mdr), which is reflected by a rapidly escalating failure of chemotherapy with different classes of cytotoxic agents: anthracyclins, vinca alkaloids, taxanes, epipodophylotoxins. Taxoids 291-298 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 19442049-1 2009 P-glycoprotein (Pgp), coded for by the mdr1 gene, is one of the ABC transporters held responsible for the phenomenon of multidrug resistance (mdr), which is reflected by a rapidly escalating failure of chemotherapy with different classes of cytotoxic agents: anthracyclins, vinca alkaloids, taxanes, epipodophylotoxins. Taxoids 291-298 ATP binding cassette subfamily B member 1 Homo sapiens 16-19 19442049-1 2009 P-glycoprotein (Pgp), coded for by the mdr1 gene, is one of the ABC transporters held responsible for the phenomenon of multidrug resistance (mdr), which is reflected by a rapidly escalating failure of chemotherapy with different classes of cytotoxic agents: anthracyclins, vinca alkaloids, taxanes, epipodophylotoxins. Taxoids 291-298 ATP binding cassette subfamily B member 1 Homo sapiens 39-43 19355888-3 2009 However, taxanes" susceptibility to drug resistance caused by the drug efflux pump protein, P-glycoprotein, is not infrequent and their use may be limited by poor solubility, synthetic problems and toxicity. Taxoids 9-16 ATP binding cassette subfamily B member 1 Homo sapiens 92-106 19470292-13 2009 This paper presents an overview of the investigations on the feasibility and application of flavonoids as P-gp modulators for improved efficacy of anti-cancer drugs like taxanes, anthracyclines, epipodophyllotoxins, camptothecins and vinca alkaloids. Taxoids 170-177 ATP binding cassette subfamily B member 1 Homo sapiens 106-110 16497442-11 2006 (3) Development of new taxanes with decreased recognition by Pgp, the product of the MDR1 gene. Taxoids 23-30 ATP binding cassette subfamily B member 1 Homo sapiens 85-89 16382445-2 2006 Expression of the multidrug transporter P-glycoprotein, encoded by the MDR1 (ABCB1) gene, is one of the causes of clinical drug resistance to taxanes. Taxoids 142-149 ATP binding cassette subfamily B member 1 Homo sapiens 71-75 16382445-2 2006 Expression of the multidrug transporter P-glycoprotein, encoded by the MDR1 (ABCB1) gene, is one of the causes of clinical drug resistance to taxanes. Taxoids 142-149 ATP binding cassette subfamily B member 1 Homo sapiens 77-82 16382445-3 2006 To study the mechanisms of MDR1 activation related to taxanes, we established 11 multidrug-resistant variants from six ovarian cancer cell lines by continuous exposure to either paclitaxel or docetaxel. Taxoids 54-61 ATP binding cassette subfamily B member 1 Homo sapiens 27-31 12711638-2 2003 TXD258, a new taxoid antitumor agent, is a poor substrate for the P-glycoprotein (P-gp) in Caco-2 cells. Taxoids 14-20 ATP binding cassette subfamily B member 1 Homo sapiens 66-80 14617793-2 2003 Although the cytotoxic taxanes paclitaxel and docetaxel are substrates for Pgp-mediated efflux, the semisynthetic taxane analogue ortataxel inhibits drug efflux mediated by Pgp as well as, as we recently demonstrated, MRP-1 and BCRP. Taxoids 23-30 ATP binding cassette subfamily B member 1 Homo sapiens 75-78 12711638-2 2003 TXD258, a new taxoid antitumor agent, is a poor substrate for the P-glycoprotein (P-gp) in Caco-2 cells. Taxoids 14-20 ATP binding cassette subfamily B member 1 Homo sapiens 82-86 12016034-2 2002 Six new taxanes are currently in clinical trials: BMS 184476, BMS 188797, BMS 275183, IDN 5109/BAY 598862, RPR 109881A et RPR 116258 All these derivatives share the same feature which is a decreased recognition by Pgp-170, the product of the MDR1 gene. Taxoids 8-15 ATP binding cassette subfamily B member 1 Homo sapiens 242-246 12548594-2 2003 In addition, it has been demonstrated that estramustine binds P-glycoprotein in vitro and, thus, may prevent the efflux of taxanes in tumors that over-express P-glycoprotein. Taxoids 123-130 ATP binding cassette subfamily B member 1 Homo sapiens 62-76 12548594-2 2003 In addition, it has been demonstrated that estramustine binds P-glycoprotein in vitro and, thus, may prevent the efflux of taxanes in tumors that over-express P-glycoprotein. Taxoids 123-130 ATP binding cassette subfamily B member 1 Homo sapiens 159-173 11801563-2 2002 This includes multidrug resistance mediated by P-glycoprotein (Pgp) to multiple lipophilic natural compounds such as taxanes, doxorubicin (Adriamycin), and vinblastine. Taxoids 117-124 ATP binding cassette subfamily B member 1 Homo sapiens 47-61 11801563-2 2002 This includes multidrug resistance mediated by P-glycoprotein (Pgp) to multiple lipophilic natural compounds such as taxanes, doxorubicin (Adriamycin), and vinblastine. Taxoids 117-124 ATP binding cassette subfamily B member 1 Homo sapiens 63-66 11466674-1 2001 BACKGROUND: Significance of Technetium 99m ((99m)Tc)-MIBI scintigraphy in the prediction of response to anthracylines and taxanes (both are substrates for P-glycoprotein [P-gp]) as well as relation between (99m)Tc-MIBI uptake and P-gp or MDR1 mRNA expression in tumors were studied in patients with breast carcinoma. Taxoids 122-129 ATP binding cassette subfamily B member 1 Homo sapiens 155-169 11504769-0 2001 Effects of orally active taxanes on P-glycoprotein modulation and colon and breast carcinoma drug resistance. Taxoids 25-32 ATP binding cassette subfamily B member 1 Homo sapiens 36-50 11466674-1 2001 BACKGROUND: Significance of Technetium 99m ((99m)Tc)-MIBI scintigraphy in the prediction of response to anthracylines and taxanes (both are substrates for P-glycoprotein [P-gp]) as well as relation between (99m)Tc-MIBI uptake and P-gp or MDR1 mRNA expression in tumors were studied in patients with breast carcinoma. Taxoids 122-129 ATP binding cassette subfamily B member 1 Homo sapiens 238-242 11104578-0 2000 Antitumour activity of novel taxanes that act at the same time as cytotoxic agents and P-glycoprotein inhibitors. Taxoids 29-36 ATP binding cassette subfamily B member 1 Homo sapiens 87-101 11104578-4 2000 These positions have been previously characterized as critical to make taxanes highly active against cells overexpressing the efflux pump P-glycoprotein (P-gp). Taxoids 71-78 ATP binding cassette subfamily B member 1 Homo sapiens 138-152 11104578-4 2000 These positions have been previously characterized as critical to make taxanes highly active against cells overexpressing the efflux pump P-glycoprotein (P-gp). Taxoids 71-78 ATP binding cassette subfamily B member 1 Homo sapiens 154-158 11104578-6 2000 Results unambiguously indicate the exceptional activity of the novel taxanes toward P-gp positive cells (up to >400 fold higher potency than that of paclitaxel). Taxoids 69-76 ATP binding cassette subfamily B member 1 Homo sapiens 84-88 11104578-11 2000 Finally, it is revealed that these novel taxanes have ability to inhibit the function of the P-gp efflux pump on the basis of the Rhodamine 123 assay. Taxoids 41-48 ATP binding cassette subfamily B member 1 Homo sapiens 93-97 11093797-1 2000 A newly synthesized taxoid originally from the Japanese yew Taxus cuspidata, 5-O-benzoylated taxinine K (BTK) was examined for its ability to reverse P-glycoprotein (P-gp) and multidrug resistance protein (MRP)-mediated multidrug resistance. Taxoids 20-26 ATP binding cassette subfamily B member 1 Homo sapiens 150-164 11062698-2 2000 At present, an MDR-1 product, the P-170 glycoprotein, is the best known of the P-170 family and is involved in resistance to natural product-based chemotherapeutics, including taxanes, anthracyclines, vinca alkaloids, podophyllotoxins and camptothecins. Taxoids 176-183 ATP binding cassette subfamily B member 1 Homo sapiens 15-20 11093797-1 2000 A newly synthesized taxoid originally from the Japanese yew Taxus cuspidata, 5-O-benzoylated taxinine K (BTK) was examined for its ability to reverse P-glycoprotein (P-gp) and multidrug resistance protein (MRP)-mediated multidrug resistance. Taxoids 20-26 ATP binding cassette subfamily B member 1 Homo sapiens 166-170 11052631-11 2000 There may be a therapeutic window for taxanes in colon cancer by optimizing pharmacokinetics and modulating MDR-1 and bcl-2 resistance factors. Taxoids 38-45 ATP binding cassette subfamily B member 1 Homo sapiens 108-113 10815934-2 2000 Because P-glycoprotein may critically influence intestinal absorption and oral bioavailability of taxanes, the purpose of the study was to evaluate the bioavailability, the pharmacokinetic behavior, and the antitumor activity of the new taxane after oral administration. Taxoids 98-105 ATP binding cassette subfamily B member 1 Homo sapiens 8-22 10815934-15 2000 The oral efficacy of the novel taxane, likely related to the inability of the P-glycoprotein to recognize the drug, which allowed an adequate intestinal absorption, is a unique feature among the taxanes and may represent a pharmacological breakthrough in their clinical use. Taxoids 195-202 ATP binding cassette subfamily B member 1 Homo sapiens 78-92 9458331-7 1998 These data confirm that the Pgp overexpression is an important mechanism of resistance to taxanes and rhizoxin in human lung and breast tumor cells. Taxoids 90-97 ATP binding cassette subfamily B member 1 Homo sapiens 28-31 10021886-8 1998 Pgp is responsible for cell resistance to cytotoxic compounds of natural origin, such as anthracyclines, vinca alkaloids, epipodophyllotoxins, taxanes, colchicine and amsacrine. Taxoids 143-150 ATP binding cassette subfamily B member 1 Homo sapiens 0-3