PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22045191-7 2012 The EMT transcription factor, ZEB1, shows altered expression in erlotinib-sensitive NSCLC and PDAC, where many signature miRNA genes are upregulated. Erlotinib Hydrochloride 64-73 zinc finger E-box binding homeobox 1 Homo sapiens 30-34 24911146-8 2014 While miR-205 depletion induced erlotinib resistance, miR-205 overexpression inhibited CRIPTO1-dependent ZEB1 and SRC activation, restoring erlotinib sensitivity. Erlotinib Hydrochloride 140-149 zinc finger E-box binding homeobox 1 Homo sapiens 105-109 19147758-0 2009 Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epidermal growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines. Erlotinib Hydrochloride 168-177 zinc finger E-box binding homeobox 1 Homo sapiens 0-42 19147758-7 2009 In contrast, the erlotinib-resistant HNSCC lines expressed high levels of the E-cadherin repressor delta-crystallin enhancer binding factor 1 (deltaEF1; Zeb-1) and other mesenchymal markers and low levels of E-cadherin, and they were highly invasive and migratory. Erlotinib Hydrochloride 17-26 zinc finger E-box binding homeobox 1 Homo sapiens 99-141 19147758-7 2009 In contrast, the erlotinib-resistant HNSCC lines expressed high levels of the E-cadherin repressor delta-crystallin enhancer binding factor 1 (deltaEF1; Zeb-1) and other mesenchymal markers and low levels of E-cadherin, and they were highly invasive and migratory. Erlotinib Hydrochloride 17-26 zinc finger E-box binding homeobox 1 Homo sapiens 143-151 19147758-7 2009 In contrast, the erlotinib-resistant HNSCC lines expressed high levels of the E-cadherin repressor delta-crystallin enhancer binding factor 1 (deltaEF1; Zeb-1) and other mesenchymal markers and low levels of E-cadherin, and they were highly invasive and migratory. Erlotinib Hydrochloride 17-26 zinc finger E-box binding homeobox 1 Homo sapiens 153-158 19147758-8 2009 Small interfering RNA-mediated knockdown of deltaEF1 in the erlotinib-resistant cell lines (1386LN and UMSCC1) resulted in up-regulation of E-cadherin and increased sensitivity to erlotinib in an E-cadherin-dependent manner. Erlotinib Hydrochloride 60-69 zinc finger E-box binding homeobox 1 Homo sapiens 44-52 19147758-8 2009 Small interfering RNA-mediated knockdown of deltaEF1 in the erlotinib-resistant cell lines (1386LN and UMSCC1) resulted in up-regulation of E-cadherin and increased sensitivity to erlotinib in an E-cadherin-dependent manner. Erlotinib Hydrochloride 180-189 zinc finger E-box binding homeobox 1 Homo sapiens 44-52 19147758-9 2009 CONCLUSIONS: DeltaEF1 controls the mesenchymal phenotype and drives erlotinib resistance in HNSCC cells. Erlotinib Hydrochloride 68-77 zinc finger E-box binding homeobox 1 Homo sapiens 13-21 26789630-9 2016 Short-interfering RNA against ZEB1 reversed the EMT phenotype and, importantly, restored erlotinib sensitivity in HCC4006ER cells. Erlotinib Hydrochloride 89-98 zinc finger E-box binding homeobox 1 Homo sapiens 30-34