PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21822619-0 2011 A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP. andrographolide 16-31 5'-nucleotidase, cytosolic II Mus musculus 163-166 21822619-7 2011 Andrographolide markedly increased cyclic GMP, but not cyclic AMP levels. andrographolide 0-15 5'-nucleotidase, cytosolic II Mus musculus 42-45 21822619-13 2011 This study demonstrates for the first time that andrographolide possesses a novel role of antiplatelet activity, which may involve the activation of the eNOS-NO/cyclic GMP pathway, resulting in the inhibition of the PI3 kinase/Akt-p38 MAPK and PLCgamma2-PKC cascades, thereby leading to inhibition of platelet aggregation. andrographolide 48-63 5'-nucleotidase, cytosolic II Mus musculus 168-171