PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34918393-7 2022 Subsequently, we confirmed that two medicinal plant-derived compounds, andrographolide, and celastrol, widely used as a nutritional or medicinal supplement are useful to attenuate DENV-induced plasma leakage through induction of the HO-1 expression in DENV-infected AG129 mice. andrographolide 71-86 heme oxygenase 1 Homo sapiens 233-237 34452191-8 2021 Additionally, FeCl3, CORM-3, biliverdin, and the HO-1 inducers andrographolide and CoPP inhibited HAV replication in the HAV-infected cells; andrographolide and CoPP exhibited a dose-dependent effect. andrographolide 63-78 heme oxygenase 1 Homo sapiens 49-53 29165873-0 2018 Andrographolide inhibits hypoxia-induced hypoxia-inducible factor 1alpha and endothelin 1 expression through the heme oxygenase 1/CO/cGMP/MKP-5 pathways in EA.hy926 cells. andrographolide 0-15 heme oxygenase 1 Homo sapiens 113-129 30414976-2 2019 Our earlier studies have demonstrated the ability of andrographolide as well as andrographolide enriched extracts to activate Nrf2/HO-1 pathway through adenosine A2a receptor. andrographolide 53-68 heme oxygenase 1 Homo sapiens 131-135 30414976-2 2019 Our earlier studies have demonstrated the ability of andrographolide as well as andrographolide enriched extracts to activate Nrf2/HO-1 pathway through adenosine A2a receptor. andrographolide 80-95 heme oxygenase 1 Homo sapiens 131-135 30414976-7 2019 Downregulation of HNF4A by andrographolide led to decrease in miRNAs regulating Heme oxygenase-1 (miR-377) and glutathione cysteine ligase (miR-433). andrographolide 27-42 heme oxygenase 1 Homo sapiens 80-96 30414976-10 2019 Overall, the work reveals that andrographolide through modulation of p53 and HNF4A, regulates miRNAs leading to upregulation of HO-1, glutathione and thioredoxin systems. andrographolide 31-46 heme oxygenase 1 Homo sapiens 128-132 29165873-11 2018 The inhibition of hypoxia-induced HIF-1alpha and ET-1 expression by andrographolide is likely associated with HO-1/CO/cGMP/MKP-5 pathways, which is involved in inhibiting hypoxia-induced p38 MAPK activation. andrographolide 68-83 heme oxygenase 1 Homo sapiens 110-117 29165873-7 2018 Andrographolide enhanced HO-1 and MKP-5 expression and cellular cGMP content in addition to inhibiting hypoxia-induced ROS generation. andrographolide 0-15 heme oxygenase 1 Homo sapiens 25-29 27297870-0 2017 Andrographolide inhibits hypoxia-induced HIF-1alpha-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells. andrographolide 0-15 heme oxygenase 1 Homo sapiens 101-105 27297870-12 2017 Taken together, these results suggest that andrographolide suppresses hypoxia-induced pro-inflammatory ET-1 expression by activating Nrf2/HO-1, inhibiting p38 MAPK signaling, and promoting PHD2/3 expression. andrographolide 43-58 heme oxygenase 1 Homo sapiens 138-142 27297870-9 2017 Silencing Nrf2 and heme oxygenase 1 (HO-1) reversed the inhibitory effects of andrographolide on hypxoia-induced HIF-1alpha mRNA and protein expression. andrographolide 78-93 heme oxygenase 1 Homo sapiens 19-35 27297870-9 2017 Silencing Nrf2 and heme oxygenase 1 (HO-1) reversed the inhibitory effects of andrographolide on hypxoia-induced HIF-1alpha mRNA and protein expression. andrographolide 78-93 heme oxygenase 1 Homo sapiens 37-41 20536138-7 2010 In parallel, andrographolide significantly induced the expression of HO-1 in a concentration-dependent fashion (p < 0.05). andrographolide 13-28 heme oxygenase 1 Homo sapiens 69-73 24117426-0 2014 Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells. andrographolide 0-15 heme oxygenase 1 Homo sapiens 72-89 24117426-7 2014 Andrographolide up-regulated the expression of haeme oxygenase-1 (HO-1), leading to increased amounts of its metabolite biliverdin, which was found to suppress HCV replication by promoting the antiviral IFN responses and inhibiting NS3/4A protease activity. andrographolide 0-15 heme oxygenase 1 Homo sapiens 47-64 24117426-7 2014 Andrographolide up-regulated the expression of haeme oxygenase-1 (HO-1), leading to increased amounts of its metabolite biliverdin, which was found to suppress HCV replication by promoting the antiviral IFN responses and inhibiting NS3/4A protease activity. andrographolide 0-15 heme oxygenase 1 Homo sapiens 66-70 24117426-8 2014 Significantly, these antiviral effects were attenuated by an HO-1-specific inhibitor or HO-1 gene knockdown, indicating that HO-1 contributed to the anti-HCV activity of andrographolide. andrographolide 170-185 heme oxygenase 1 Homo sapiens 61-65 24117426-8 2014 Significantly, these antiviral effects were attenuated by an HO-1-specific inhibitor or HO-1 gene knockdown, indicating that HO-1 contributed to the anti-HCV activity of andrographolide. andrographolide 170-185 heme oxygenase 1 Homo sapiens 88-92 24117426-8 2014 Significantly, these antiviral effects were attenuated by an HO-1-specific inhibitor or HO-1 gene knockdown, indicating that HO-1 contributed to the anti-HCV activity of andrographolide. andrographolide 170-185 heme oxygenase 1 Homo sapiens 88-92 23146110-12 2013 Andrographolide up-regulated ARE-regulated gene targets including glutamate-cysteine ligase catalytic (GCLC) subunit, GCL modifier (GCLM) subunit, GPx, GR and heme oxygenase-1 in BEAS-2B cells in response to CSE. andrographolide 0-15 heme oxygenase 1 Homo sapiens 159-175 27418236-0 2016 Andrographolide protects liver cells from H2O2 induced cell death by upregulation of Nrf-2/HO-1 mediated via adenosine A2a receptor signalling. andrographolide 0-15 heme oxygenase 1 Homo sapiens 91-95 27418236-6 2016 RESULTS: We clearly show that andrographolide via adenosine A2A receptor signalling leads to activation of p38 MAP kinase, resulting in upregulation of Nrf-2, its translocation to nucleus and activation of HO-1. andrographolide 30-45 heme oxygenase 1 Homo sapiens 206-210 27418236-9 2016 CONCLUSIONS: Thus, andrographolide probably by binding to adenosine A2a receptor activates Nrf-2 transcription and also inhibits its exclusion from the nucleus by inactivating GSK-3beta, together resulting in activation of HO-1. andrographolide 19-34 heme oxygenase 1 Homo sapiens 223-227 24998495-0 2014 Andrographolide inhibits TNFalpha-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells. andrographolide 0-15 heme oxygenase 1 Homo sapiens 121-125 24998495-7 2014 Andrographolide induced the gene expression of heme oxygenase 1 (HO-1) and glutamate cysteine ligase modifier subunit (GCLM) in a time-dependent manner. andrographolide 0-15 heme oxygenase 1 Homo sapiens 47-63 24998495-7 2014 Andrographolide induced the gene expression of heme oxygenase 1 (HO-1) and glutamate cysteine ligase modifier subunit (GCLM) in a time-dependent manner. andrographolide 0-15 heme oxygenase 1 Homo sapiens 65-69 24998495-11 2014 The mechanism underlying the up-regulation of HO-1 and GCLM by andrographolide was dependent on the PI3K/Akt pathway, and both the Nrf2 and AP-1 transcriptional factors were involved. andrographolide 63-78 heme oxygenase 1 Homo sapiens 46-50 24998495-12 2014 Our results suggest that andrographolide attenuates TNFalpha-induced ICAM-1 expression at least partially through suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression, which is PI3K/Akt pathway-dependent. andrographolide 25-40 heme oxygenase 1 Homo sapiens 171-175 24117426-9 2014 Andrographolide activated p38 MAPK phosphorylation, which stimulated nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated HO-1 expression, and this was found to be associated with its anti-HCV activity. andrographolide 0-15 heme oxygenase 1 Homo sapiens 129-133 24117426-10 2014 CONCLUSIONS AND IMPLICATIONS: Our results demonstrate that andrographolide has the potential to control HCV replication and suggest that targeting the Nrf2-HO-1 signalling pathway might be a promising strategy for drug development. andrographolide 59-74 heme oxygenase 1 Homo sapiens 156-160 20536138-9 2010 Transfection with HO-1-specific small interfering RNA knocked down HO-1 expression, and the inhibition of expression of ICAM-1 by andrographolide was significantly reversed. andrographolide 130-145 heme oxygenase 1 Homo sapiens 18-22 20536138-10 2010 These results suggest that stimulation of Nrf2-dependent HO-1 expression is involved in the suppression of TNF-alpha-induced ICAM-1 expression exerted by andrographolide. andrographolide 154-169 heme oxygenase 1 Homo sapiens 57-61