PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23261362-0	2013	CHP1002, a novel andrographolide derivative, inhibits pro-inflammatory inducible nitric oxide synthase and cyclooxygenase-2 expressions in RAW264.7 macrophages via up-regulation of heme oxygenase-1 expression.	andrographolide	17-32	heme oxygenase 1	Rattus norvegicus	181-197	
35305248-0	2022	Andrographolide Attenuates Blood-Brain Barrier Disruption, Neuronal Apoptosis, and Oxidative Stress Through Activation of Nrf2/HO-1 Signaling Pathway in Subarachnoid Hemorrhage.	andrographolide	0-15	heme oxygenase 1	Rattus norvegicus	127-131	
35305248-10	2022	Our research suggested that Andro alleviated BBB disruption, neuronal apoptosis, and oxidative stress in SAH, possibly via the Nrf2/HO-1 signaling pathway.	andrographolide	28-33	heme oxygenase 1	Rattus norvegicus	132-136	
26746802-0	2016	Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats.	andrographolide	0-15	heme oxygenase 1	Rattus norvegicus	108-124	
26746802-4	2016	We determined that andrographolide modulates the mitogen-activated protein kinase (MAPK)-Nrf2-HO-1 signaling cascade in primary cerebral endothelial cells (CECs) to provide positive protection against middle cerebral artery occlusion (MCAO)-induced ischemic stroke in rats.	andrographolide	19-34	heme oxygenase 1	Rattus norvegicus	94-98	
26746802-5	2016	In the present study, andrographolide (10 muM) increased HO-1 protein and messenger RNA expressions, Nrf2 phosphorylation, and nuclear translocation in CECs, and these activities were disrupted by a p38 MAPK inhibitor, SB203580, but not by the extracellular signal-regulated kinase inhibitor PD98059 or c-Jun amino-terminal kinase inhibitor SP600125.	andrographolide	22-37	heme oxygenase 1	Rattus norvegicus	57-61	
26746802-7	2016	Moreover, andrographolide-induced Nrf2 and HO-1 protein expressions were significantly inhibited by Nrf2 small interfering RNA.	andrographolide	10-25	heme oxygenase 1	Rattus norvegicus	43-47	
26746802-8	2016	Moreover, HO-1 knockdown attenuated the protective effect of andrographolide against oxygen-glucose deprivation-induced CEC death.	andrographolide	61-76	heme oxygenase 1	Rattus norvegicus	10-14	
26746802-9	2016	Andrographolide (0.1 mg/kg) significantly suppressed free radical formation, blood-brain barrier disruption, and brain infarction in MCAO-insulted rats, and these effects were reversed by the HO-1 inhibitor zinc protoporphyrin IX.	andrographolide	0-15	heme oxygenase 1	Rattus norvegicus	192-196	
26746802-10	2016	The mechanism is attributable to HO-1 activation, as directly evidenced by andrographolide-induced pronounced HO-1 expression in brain tissues, which was highly localized in the cerebral capillary.	andrographolide	75-90	heme oxygenase 1	Rattus norvegicus	33-37	
26746802-10	2016	The mechanism is attributable to HO-1 activation, as directly evidenced by andrographolide-induced pronounced HO-1 expression in brain tissues, which was highly localized in the cerebral capillary.	andrographolide	75-90	heme oxygenase 1	Rattus norvegicus	110-114	
26746802-11	2016	In conclusion, andrographolide increased Nrf2-HO-1 expression through p38 MAPK regulation, confirming that it provides protection against MCAO-induced brain injury.	andrographolide	15-30	heme oxygenase 1	Rattus norvegicus	46-50	
25110055-6	2014	The results showed that andrographolide up-regulated glutamate cysteine ligase (GCL) catalytic and modifier subunits, superoxide dismutase (SOD)-1, heme oxygenase (HO)-1, and glutathione (GSH) S-transferase (GST) Ya/Yb protein and mRNA expression in the liver, heart, and kidneys.	andrographolide	24-39	heme oxygenase 1	Rattus norvegicus	148-169	
31562575-5	2019	Moreover, mechanism study revealed that the anti-inflammatory activity of andrographolide may be related to the suppression of nuclear translocation of NF-kappaB as well as the activation of Nrf2 and HO-1.	andrographolide	74-89	heme oxygenase 1	Rattus norvegicus	200-204	
31562575-8	2019	In conclusion, andrographolide protected neurons against inflammation-mediated injury via NF-kappaB inhibition and Nrf2/HO-1 activation and resisted oxidative damage via inhibiting ROS production.	andrographolide	15-30	heme oxygenase 1	Rattus norvegicus	120-124