PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29165873-10	2018	Moreover, silencing MKP-5 or treatment with the phosphatase inhibitor vanadate abrogated andrographolide"s suppressing hypoxia-induced p38 MAPK activation and HIF-1alpha expression.	andrographolide	89-104	mitogen-activated protein kinase 14	Homo sapiens	135-138	
31404237-8	2019	Moreover, andrographolide induced the phosphorylation of Jun N-terminus kinase (JNK) and p-38 Mitogen-activated protein kinase (MAPK).	andrographolide	10-25	mitogen-activated protein kinase 14	Homo sapiens	89-126	
29165873-11	2018	The inhibition of hypoxia-induced HIF-1alpha and ET-1 expression by andrographolide is likely associated with HO-1/CO/cGMP/MKP-5 pathways, which is involved in inhibiting hypoxia-induced p38 MAPK activation.	andrographolide	68-83	mitogen-activated protein kinase 14	Homo sapiens	187-190	
27114702-0	2016	Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemia Jurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways.	andrographolide	0-15	mitogen-activated protein kinase 14	Homo sapiens	140-143	
27297870-12	2017	Taken together, these results suggest that andrographolide suppresses hypoxia-induced pro-inflammatory ET-1 expression by activating Nrf2/HO-1, inhibiting p38 MAPK signaling, and promoting PHD2/3 expression.	andrographolide	43-58	mitogen-activated protein kinase 14	Homo sapiens	155-158	
27418236-6	2016	RESULTS: We clearly show that andrographolide via adenosine A2A receptor signalling leads to activation of p38 MAP kinase, resulting in upregulation of Nrf-2, its translocation to nucleus and activation of HO-1.	andrographolide	30-45	mitogen-activated protein kinase 14	Homo sapiens	107-110	
22537555-0	2012	Andrographolide exerted its antimicrobial effects by upregulation of human beta-defensin-2 induced through p38 MAPK and NF-kappaB pathway in human lung epithelial cells.	andrographolide	0-15	mitogen-activated protein kinase 14	Homo sapiens	107-115	
24117426-9	2014	Andrographolide activated p38 MAPK phosphorylation, which stimulated nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated HO-1 expression, and this was found to be associated with its anti-HCV activity.	andrographolide	0-15	mitogen-activated protein kinase 14	Homo sapiens	26-29	
24117426-0	2014	Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells.	andrographolide	0-15	mitogen-activated protein kinase 14	Homo sapiens	98-101